Intermittent Theta Burst Stimulation Increases Reward Responsiveness in Individuals with Higher Hedonic Capacity.
Intermittent Theta Burst Stimulation Increases Reward Responsiveness in Individuals with Higher Hedonic Capacity.
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DOI：
10.3389/fnhum.2016.00294
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发表时间：
2016
影响因子：
2.9
通讯作者：
Baeken C
中科院分区：
文献类型：
--
作者：
Duprat R;De Raedt R;Wu GR;Baeken C
背景资料：在左背外侧前额叶皮层（DLPFC）重复经颅磁刺激已被证明影响纹状体和眶额多巴胺能活动涉及奖励处理。然而，DLPFC刺激如何影响奖励系统以及特质享乐能力如何与这些影响相互作用的确切神经心理学机制仍有待阐明。目的：在这项健康个体的假对照研究中，我们研究了单次神经导航间歇性θ爆发刺激（iTBS）对奖励反应的影响，以及特质享乐能力的影响。方法：我们采用随机交叉单次iTBS设计，间隔1周。我们使用奖励概率学习任务评估奖励反应性，并使用快乐量表问卷测量个体特质快乐能力（体验快乐的能力）。结果：正如预期的那样，参与者对最有回报的刺激（丰富的刺激）产生了反应偏见。丰富的刺激的反应时间和准确性分别较短和较高相比，奖励较少的刺激（瘦刺激）。主动或假刺激似乎不影响结果。然而，当考虑到个人特质享乐能力，我们发现一个早期显着增加的反应偏差后，积极的iTBS。个体的特质享乐能力越高，在主动刺激后对丰富刺激的反应偏向增加越多。结论：当考虑到特质享乐能力，一个积极的iTBS会议在左DLPFC改善奖励反应性健康男性参与者具有较高的享乐能力。这表明，个体差异的享乐能力可能会影响iTBS的奖励系统的效果。
Background: Repetitive transcranial magnetic stimulation over the left dorsolateral prefrontal cortex (DLPFC) has been documented to influence striatal and orbitofrontal dopaminergic activity implicated in reward processing. However, the exact neuropsychological mechanisms of how DLPFC stimulation may affect the reward system and how trait hedonic capacity may interact with the effects remains to be elucidated. Objective: In this sham-controlled study in healthy individuals, we investigated the effects of a single session of neuronavigated intermittent theta burst stimulation (iTBS) on reward responsiveness, as well as the influence of trait hedonic capacity. Methods: We used a randomized crossover single session iTBS design with an interval of 1 week. We assessed reward responsiveness using a rewarded probabilistic learning task and measured individual trait hedonic capacity (the ability to experience pleasure) with the temporal experience of pleasure scale questionnaire. Results: As expected, the participants developed a response bias toward the most rewarded stimulus (rich stimulus). Reaction time and accuracy for the rich stimulus were respectively shorter and higher as compared to the less rewarded stimulus (lean stimulus). Active or sham stimulation did not seem to influence the outcome. However, when taking into account individual trait hedonic capacity, we found an early significant increase in the response bias only after active iTBS. The higher the individual's trait hedonic capacity, the more the response bias toward the rich stimulus increased after the active stimulation. Conclusion: When taking into account trait hedonic capacity, one active iTBS session over the left DLPFC improved reward responsiveness in healthy male participants with higher hedonic capacity. This suggests that individual differences in hedonic capacity may influence the effects of iTBS on the reward system.