Neuropeptide S reduces fear and avoidance of con-specifics induced by social fear conditioning and social defeat, respectively
Neuropeptide S reduces fear and avoidance of con-specifics induced by social fear conditioning and social defeat, respectively
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DOI：
10.1016/j.neuropharm.2016.03.054
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发表时间：
2016-09
影响因子：
4.7
通讯作者：
Iulia Zoicas;R. Menon;I. Neumann
中科院分区：
文献类型：
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作者：
Iulia Zoicas;R. Menon;I. Neumann
神经肽S（Neuropeptide S，PSV）具有抗焦虑作用，并能消除啮齿类动物的恐惧感.在这里，我们调查是否逆转社会恐惧和社会回避引起的社会恐惧条件反射（SFC）和急性社会失败（SD），分别在雄性CD 1小鼠。我们的研究结果表明，侧脑室给药（icv; 10和50 nmol/2 μl）逆转了SFC诱导的对未知同种的恐惧，并剂量依赖性地减少了SD诱导的对已知攻击性同种的回避。虽然50 nmol的NH3完全逆转了社交回避并恢复了社交偏好，但10 nmol的NH3减少了社交回避，但没有完全恢复社交失败小鼠的社交偏好。此外，较低剂量（1 nmol/2 μl）的多巴胺促进了线索恐惧的消退，而较高剂量（10 nmol/2 μl）则减少了线索恐惧的表达。我们还可以证实，在高架十字迷宫（ESTA）上，ESTA（1，10和50 nmol/2 μl）的抗焦虑作用，这并不伴随着在ESTA或在家庭笼中的自发活动的改变。最后，我们可以证明icv输注D-Cys（tBu）5-Cys（10 nmol/2 μl）不改变SFC诱导的社交恐惧、一般焦虑和运动活动。两者合计，我们的研究扩展了有效的抗焦虑的个人资料，以证明减少社会恐惧和社会回避的社会背景，从而提供了框架的研究调查参与的神经系统在调节不同类型的社会行为。
Neuropeptide S (NPS) has anxiolytic effects and facilitates extinction of cued fear in rodents. Here, we investigated whether NPS reverses social fear and social avoidance induced by social fear conditioning (SFC) and acute social defeat (SD), respectively, in male CD1 mice. Our results revealed that intracerebroventricular NPS (icv; 10 and 50 nmol/2 μl) reversed fear of unknown con-specifics induced by SFC and dose-dependently reduced avoidance of known aggressive con-specifics induced by SD. While 50 nmol of NPS completely reversed social avoidance and reinstated social preference, 10 nmol of NPS reduced social avoidance, but did not completely reinstate social preference in socially-defeated mice. Further, a lower dose (1 nmol/2 μl) of NPS facilitated the within-session extinction of cued fear, while a higher dose (10 nmol/2 μl) reduced the expression of cued fear. We could also confirm the anxiolytic effects of NPS (1, 10 and 50 nmol/2 μl) on the elevated plus-maze (EPM), which were not accompanied by alterations in locomotor activity either on the EPM or in the home cage. Finally, we could show that icv infusion of the NPS receptor 1 antagonist D-Cys(tBu)5-NPS (10 nmol/2 μl) did not alter SFC-induced social fear, general anxiety and locomotor activity. Taken together, our study extends the potent anxiolytic profile of NPS to a social context by demonstrating the reduction of social fear and social avoidance, thus providing the framework for studies investigating the involvement of the NPS system in the regulation of different types of social behaviour.