Ozone exposure increases eosinophilic airway response induced by previous allergen challenge
Ozone exposure increases eosinophilic airway response induced by previous allergen challenge
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DOI：
10.1164/rccm.2201013
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发表时间：
2002-10-15
影响因子：
24.7
通讯作者：
Paggiaro, PL
中科院分区：
文献类型：
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作者：
Vagaggini, B;Taccola, M;Paggiaro, PL
我们调查了在过敏原激发试验后24小时暴露于臭氧(O-3)是否会增加轻度哮喘患者中由过敏原引起的气道嗜酸性粒细胞增多症。12名患有轻度特应性哮喘的受试者参加了一项随机、单盲研究。受试者在接触O-3(0.27ppm)或过滤空气2小时前24小时接受过敏原激发。在过敏原攻击期间和接触O-3或空气后监测肺功能。6小时后收集诱导痰。4周后，对相同的受试者重复实验。在这两个挑战中，变应原诱导了类似的晚期呼吸道反应。与空气接触相比，接触O-3导致FVC、FEV1和肺活量显著下降，并与总症状评分显著增加有关。O-3暴露后诱导痰中嗜酸性粒细胞百分比显著高于空气暴露后(p=0.04)，但中性粒细胞百分比未见明显变化。这些结果表明，在轻度特应性哮喘患者中，在过敏原激发的晚期呼吸道反应后暴露O-3可以增强由过敏原激发本身引起的嗜酸性炎症反应。这一观察结果可能有助于解释空气污染和过敏原暴露在哮喘恶化中的协同作用。
We investigated whether exposure to ozone (O-3) 24 hours after an allergen challenge test would increase airway eosinophilia induced by allergen in subjects with mild asthma with late airway response. Twelve subjects with mild atopic asthma participated in a randomized, single-blind study. Subjects underwent allergen challenge 24 hours before a 2 hour exposure to O-3 (0.27 ppm) or filtered air. Pulmonary function was monitored during the allergen challenge and after the exposure to O-3 or air. Six hours later, induced sputum was collected. After 4 weeks, the experiment was repeated with the same subjects. Allergen induced a comparable late airway response in both challenges. O-3 exposure induced a significant decrease in FVC, FEV1, and vital capacity, and was associated with a significant increase in total symptom score compared with air exposure. The percentage of eosinophils, but not the percentage of neutrophils, in induced sputum was significantly higher after exposure to O-3 than after exposure to air (p = 0.04). These results indicate that O-3 exposure after a late airway response elicited by allergen challenge can potentiate the eosinophilic inflammatory response induced by the allergen challenge itself in subjects with mild atopic asthma. This observation may help explain the synergistic effect of air pollution and allergen exposure in the exacerbation of asthma.