SIMILARITY OF SECRETORY PROTEIN-I FROM PARATHYROID-GLAND TO CHROMOGRANIN-A FROM ADRENAL-MEDULLA
SIMILARITY OF SECRETORY PROTEIN-I FROM PARATHYROID-GLAND TO CHROMOGRANIN-A FROM ADRENAL-MEDULLA
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DOI：
10.1073/pnas.79.19.6056
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
WINKLER, H
中科院分区：
文献类型：
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作者：
COHN, DV;ZANGERLE, R;WINKLER, H
比较了[牛]甲状旁腺分泌蛋白I和肾上腺嗜铬粒蛋白A的氨基酸和碳水化合物组成、部分氨基酸序列、免疫交叉反应性和物理性质。这种比较表明这些蛋白质是相似的分子。因为分泌蛋白I存在于含有甲状旁腺素的分泌颗粒中，并与激素共同分泌，并且因为嗜铬粒蛋白A包含在嗜铬颗粒中，并与儿茶酚胺一起分泌，所以目前的观察提高了这类蛋白在激素分泌或储存机制中起一般作用的可能性。
The amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity and physical properties of secretory protein I of the [bovine] parathyroid gland and chromogranin A of adrenal gland were compared. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.