Survival trends in mantle cell lymphoma in the United States over 16 years 1992-2007
Survival trends in mantle cell lymphoma in the United States over 16 years 1992-2007
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DOI：
10.3109/10428194.2012.656628
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发表时间：
2012-08-01
影响因子：
2.6
通讯作者：
Spurgeon, Stephen E.
中科院分区：
文献类型：
--
作者：
Chandran, Rekha;Gardiner, Stuart K.;Spurgeon, Stephen E.
使用监测、流行病学和最终结果 (SEER) 数据库进行回顾性分析，以确定套细胞淋巴瘤 (MCL) 患者的总体生存趋势并确定预后因素。 1992年至2007年期间总共发现了5367例MCL病例，分为三个队列：第1组（1992-1999年）、第2组（2000-2003年）和第3组（2004-2007年）。使用 Cox 比例风险模型对生存率进行分析，以校正年龄、性别和疾病阶段。诊断时患有晚期疾病的患者比例、男性和高龄患者的比例随着时间的推移而增加，这些都与死亡率的增加有关。总生存率保持不变。然而，当根据上述预后不良的患者比例增加进行调整后，我们发现生存率显着提高。调整后的模型还显示晚期患者的预测生存率随着时间的推移有所改善。局部疾病患者的生存率没有变化。尽管该分析并非旨在评估特定的治疗方式，但这些数据表明，过去十年中新治疗策略的发展可能会影响晚期 MCL 患者的生存，尽管发现美国普通人群的总体生存率保持不变。
A retrospective analysis was done using the Surveillance, Epidemiology, and End-Results (SEER) database to determine the trends in overall survival and identify prognostic factors in patients with mantle cell lymphoma (MCL). In total 5367 cases of MCL identified from 1992 to 2007 were split into three cohorts, group 1(1992-1999), group 2 (2000-2003) and group 3 (2004-2007). Survival was analyzed using the Cox proportional hazards model to correct for age, gender and stage of disease. The proportion of patients with advanced disease at diagnosis, male gender and advanced age increased over time and these were all associated with increased mortality. The overall survival remained unchanged. However, when adjusted for the increased proportion of patients with poor prognostic features noted above, we found a significant improvement in survival. The adjusted model also showed an improvement in predicted survival over time in patients with advanced stage. No change in survival was seen in patients with localized disease. Although this analysis is not designed to evaluate specific treatment modalities, these data suggest that the development of new treatment strategies over the past decade may be impacting the survival of patients with advanced MCL despite the finding that the overall survival remains unchanged in the general US population.