Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study
Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study
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DOI：
10.1007/s00586-014-3333-8
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发表时间：
2014-09-01
影响因子：
2.8
通讯作者：
Williams, Frances M. K.
中科院分区：
文献类型：
--
作者：
Maatta, Juhani H.;Kraatari, Minna;Williams, Frances M. K.
旨在研究经典双胞胎研究中椎体终板或 Modic 改变 (MC) 的患病率、10 年随访中 MC 的进展以及 MC 患病率的遗传性。研究人群于 1996 年至 2000 年间从 TwinsUK 登记库中招募。在基线和随访时通过 T2 加权腰椎磁共振成像 (MRI) 评估 MC。使用方差成分分析估计遗传力。 831 名双胞胎可获得具有适当数据的基线 MRI，并对 436 名双胞胎进行了随访。总共有 347 名双胞胎的基线和随访影像均可用。研究人群的平均年龄为 54.1 岁（范围 45.7-62.5），女性占 96%。基线时 MC 的患病率为 32.1%，随访时为 48.4%。 10年随访期间MC的发生率为21.6%，L4-5和L5-S1最高。 3.5% 的双胞胎中 MC 完全消退。与没有基线 MC 的双胞胎相比，基线时患有 MC 的双胞胎在随访期间表现出上腰椎水平的 MC 发生率更高 (p = 0.009)。同卵双胞胎的先证一致性率 (0.56) 高于异卵双胞胎 (0.39)，表明存在家族影响。 MC患病率的遗传力估计为30(16-43)%。结果表明MC通常在中年进展并且具有遗传性。由于 MC 与椎间盘退变有关，而椎间盘退变也是可遗传的，因此需要进一步研究潜在的共享机制。
To study the prevalence of vertebral endplate or Modic change (MC), the progression of MC over a 10-year follow-up and the heritability of MC prevalence in a classical twin study.The study population was recruited from TwinsUK register between 1996 and 2000. MC was evaluated from T2-weighted lumbar magnetic resonance imaging (MRI) at baseline and follow-up. Heritability was estimated using variance components analysis. Baseline MRI with appropriate data was available for 831 twins and follow-up for 436 twins. In total, both baseline and follow-up imaging were available for 347 twins.Mean age of the study population was 54.1 years (range 45.7-62.5) and females comprised 96 %. The prevalence of MC at baseline was 32.1 % and at follow-up 48.4 %. The incidence of MC during the 10-year follow-up was 21.6 % and was highest at L4-5 and L5-S1. MC regressed totally in 3.5 % of twins. Twins with prevalent MC at baseline demonstrated a higher incidence of MC at upper lumbar levels during follow-up compared to twins without baseline MC (p = 0.009). Probandwise concordance rates were higher in monozygotic (0.56) than dizygotic twin pairs (0.39) suggestive of familial influence. Heritability of MC prevalence was estimated at 30 (16-43) %.The results suggest that MC is generally progressive in middle age and furthermore is heritable. Since MC is associated with disc degeneration, which is also heritable, further work on potential shared mechanisms is needed.