Spine motility with synaptic contact
Spine motility with synaptic contact
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DOI：
10.1038/89460
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发表时间：
2001-07-01
影响因子：
25
通讯作者：
Mason, C
中科院分区：
文献类型：
--
作者：
Dunaevsky, A;Blaszeski, R;Mason, C
树突状突起，包括丝状足突和棘突，是高度动态的1、2、3，但它们的运动在多大程度上依赖于传入神经或突触活动仍在争论2、3、4、5、6、7、8。通过用双光子显微镜监测小脑切片中标记的浦肯野细胞的树突棘，然后对相同成像的棘进行超微结构分析，我们表明，即使树突棘与突触前终末接触，它们也可以表现出形态重排。
Dendritic protrusions, including filopodia and spines, are highly dynamic 1, 2, 3, but the extent to which their motility depends on afferent innervation or synaptic activity is under debate 2, 3, 4, 5, 6, 7, 8. By monitoring dendritic spines of labeled Purkinje cells in cerebellar slices by two-photon microscopy, followed by ultrastructural analysis of the same imaged spines, we show that dendritic spines can exhibit morphological rearrangements even when they are contacted by presynaptic terminals.