Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of Enterococcus faecalis and its analogs
Chemical synthesis and biological activity of the gelatinase biosynthesis-activating pheromone of Enterococcus faecalis and its analogs
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DOI：
10.1271/bbb.65.2322
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发表时间：
2001-10-01
影响因子：
1.6
通讯作者：
Nagasawa, H
中科院分区：
文献类型：
--
作者：
Nakayama, J;Cao, Y;Nagasawa, H
明胶酶生物合成激活信息素（GBAP）是一种11个残基的肽内酯，它能触发粪肠球菌中致病性相关的胞外蛋白酶明胶酶和丝氨酸蛋白酶的产生。在这项研究中，我们合成了GBAP及其类似物，并研究了它们的明胶酶生物合成诱导活性。构效关系的研究表明，内酯环是活性不可缺少的环。
An 11-residue peptide lactone, termed the gelatinase biosynthesis-activating pheromone (GBAP), triggers the production of the pathogenicity-related extracellular proteases, gelatinase and serine protease, in Enterococcus faecalis. In this study, we synthesized GBAP and its analogs and examined their gelatinase biosynthesis-inducing activity. This study on the structure-activity relationship shows that a lactone ring was indispensable for the activity.