The Irreversibly Sickled Cell; a Determinant of Haemolysis in Sickle Cell Anaemia
The Irreversibly Sickled Cell; a Determinant of Haemolysis in Sickle Cell Anaemia
复制标题
不可逆的镰状细胞；
DOI：
10.1111/j.1365-2141.1969.tb01403.x
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发表时间：
1969
影响因子：
6.5
通讯作者：
P. F. Milner
中科院分区：
文献类型：
--
作者：
G. R. Serjeant;B. Serjeant;P. F. Milner
摘要红细胞存活率估计在一组成人镰状细胞贫血患者使用51铬技术。在毛细血管血的薄盖玻片制备物上进行不可逆镰状细胞计数。这些计数在同一个体内相对恒定，但在个体之间显示出明显的差异。已证明不可逆镰状细胞计数和红细胞存活率之间存在显著相关性。这种相关性并不适用于镰状细胞贫血伴脾肿大的患者，他们的不可逆镰状细胞计数总是很低。
Summary. Red cell survival was estimated in a group of adult sickle cell anaemia patients using the 51Cr technique. Counts of irreversibly sickled cells were performed on thin coverslip preparations of capillary blood. These counts are relatively constant within the same individual but show marked variations between individuals. A significant correlation has been demonstrated between the irreversibly sickled cell count and the red cell survival. This correlation does not apply to sickle cell anaemia patients with splenomegaly in whom the irreversibly sickled cell count is always low.