LYMPHOCYTE-T FUNCTION DURING EXPERIMENTAL CHAGAS-DISEASE - PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2
LYMPHOCYTE-T FUNCTION DURING EXPERIMENTAL CHAGAS-DISEASE - PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2
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DOI：
10.1002/eji.1830150505
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
EISEN, H
中科院分区：
文献类型：
--
作者：
HARELBELLAN, A;JOSKOWICZ, M;EISEN, H
感染克氏锥虫的小鼠会导致严重的免疫抑制，伴随着自身免疫症状的出现。我们以前已经表明，增殖和白细胞介素2的产生伴刀豆球蛋白A刺激的T细胞从感染的小鼠是严重抑制。在这项研究中，我们表明，至少有两种现象是负责这种抑郁症。第一次混合实验表明，在感染动物的脾脏中，存在粘附的、Thy-1阴性的和抗辐射的抑制细胞。其次，通过有限稀释法对富集的T细胞群和前体的分析研究表明，在感染的动物中，T细胞区室本身受损：富集的T细胞的反应，即使用正常辅助细胞重建，也仅达到正常未感染小鼠的40%。
Infection of mice with Trypanosoma cruzi results in a severe immunosuppression, accompanied by the appearance of autoimmune symptoms. We have previously shown that proliferation and interleukin 2 production by concanavalin A-stimulated T cells from infected mice is severely depressed. In this study we show that at least two phenomena are responsible for this depression. First mixing experiments showed the existence, in spleens of infected animals, of adherent, Thy-1-negative and radioresistant suppressor cells. Second, studies of enriched T cell populations and analysis of precursors by limiting dilution showed that the T cell compartment itself was impaired in infected animals: responses of enriched T cells, even when reconstituted with normal accessory cells, reached only 40% of those obtained with normal uninfected mice.