Heading direction with respect to a reference point modulates place-cell activity
Heading direction with respect to a reference point modulates place-cell activity
复制标题
DOI：
10.1038/s41467-019-10139-7
复制
发表时间：
2019-05-27
影响因子：
16.6
通讯作者：
Kandel, E. R.
中科院分区：
文献类型：
--
作者：
Jercog, P. E.;Ahmadian, Y.;Kandel, E. R.
海马CA1区神经元的调节是通过来自不同感觉模式的非空间输入和动物相对于所导航的空间范围的位置和方向的空间信息的组合而出现的。CA1神经元反应的位置调节（如位置调谐）已被广泛研究，但对这些神经元的方向调节知之甚少。在这里，利用自由运动小鼠的CA1锥体细胞的电生理记录，我们报告说，大多数神经反应是由动物相对于其围栏内外的一个点的前进方向调节的，我们称之为参考点。相对于参考点的朝向调制的发现确定了海马背侧神经元反应中编码的一种新表征。
The tuning of neurons in area CA1 of the hippocampus emerges through a combination of non-spatial input from different sensory modalities and spatial information about the animal's position and heading direction relative to the spatial enclosure being navigated. The positional modulation of CA1 neuronal responses has been widely studied (e.g. place tuning), but less is known about the modulation of these neurons by heading direction. Here, utilizing electro physiological recordings from CA1 pyramidal cells in freely moving mice, we report that a majority of neural responses are modulated by the heading-direction of the animal relative to a point within or outside their enclosure that we call a reference point. The finding of heading-direction modulation relative to reference points identifies a novel representation encoded in the neuronal responses of the dorsal hippocampus.