[Regulation of fetal placental circulation].
[Regulation of fetal placental circulation].
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DOI：
10.1016/s1297-9589(01)00177-1
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发表时间：
2001-07-01
期刊：
影响因子：
--
通讯作者：
Ferre, F
中科院分区：
文献类型：
--
作者：
Ferre, F
胎胎盘循环的发育和反应似乎是非常协调的现象，遵循精确的时间顺序，并受许多血管生成和血管活性因子的调节。绒毛血管的内皮，由于其释放血管舒张物质的能力，似乎在胎盘血管阻力的逐渐降低中起着至关重要的作用，从而使其能够满足胎儿不断增长的需求，直到怀孕结束。在内皮中，就像在胎盘血管的平滑肌中一样，胎盘张力的信号调节剂（内皮素1、一氧化氮、前列腺素等）的产生和作用机制的控制以及它们对氧的依赖性还远未完全阐明。研究它们之间的相互作用有助于更好地评估它们在正常妊娠不同阶段建立的特定平衡中的相对重要性，以及在胎盘血流和胎儿发育受到损害的病理情况下（先兆子痫、宫内生长迟缓等）。
The development and the reactivity of fetoplacental circulation appear to be extremely well coordinated phenomena which follow a precise chronology and are regulated by numerous angiogenic and vasoactive factors. The endothelium of the villous vessels, due to its capacity to release vasodilatating substances, would appear to play a crucial role in the gradual decrease in the vascular resistance of the placenta, thereby enabling it to meet the growing needs of the fetus right up until the end of pregnancy. In the endothelium, as in the smooth muscle of the placental vessels, control of production and mechanisms of action of the signal modulators of placental tone--endothelin 1, nitric oxide, prostanoids, etc.--as well as their dependence on oxygen, are far from being entirely elucidated. The study of their interactions could contribute to better evaluating the relative importance of each of them in the particular balances which are established at different stages of normal pregnancy, as well as during pathological situations (pre-eclampsia, intrauterine growth retardation, etc.) when placental blood flow and fetal development are at risk of being compromised.