ACUTE REDUCTION OF PLASMA NONESTERIFIED FATTY ACID BY GROWTH HORMONE IN HYPOPHYSECTOMIZED AND HOUSSAY RATS.
ACUTE REDUCTION OF PLASMA NONESTERIFIED FATTY ACID BY GROWTH HORMONE IN HYPOPHYSECTOMIZED AND HOUSSAY RATS.
复制标题
生长激素对垂体切除大鼠和 HOUSSAY 大鼠血浆非酯化脂肪酸的急性减少。
DOI：
10.1210/endo-76-4-665
复制
发表时间：
1965
期刊：
影响因子：
4.8
通讯作者：
C. M. Szego
中科院分区：
文献类型：
--
作者：
N. I. Swislocki;C. M. Szego
对垂体切除的 Sprague-Dawley 大鼠腹腔内注射 1 或 3 mg 牛生长激素（GH、NIH-916），在 30 分钟和 60 分钟时引起血浆非酯化脂肪酸（NEFA）的减少。这些影响明显不同于常见的 2-6 小时观察到的升高。低血糖和低氨基酸血症与血浆 NEFA 下降暂时相关，6 小时时附睾脂肪垫显示相对水含量增加，作为强烈脂质动员的间接证据。在切除垂体前 3-5 天进行胰腺次全切除术 (95%)，未能阻止 GH 引起的血浆 NEFA 1 小时减少。比所用较大 GH 剂量中最大污染物计算值大 3 倍的 ACTH 剂量未能引起 1 小时 NEFA 下降。血浆 NEFA 的急剧减少强烈表明，仅从时间关系来看，脂肪运动反应并不是 GH 的主要作用。 （内分泌学 76：665，1965）
Intraperitoneal administration of 1 or 3 mg of bovine growth hormone (GH, NIH-916) to hypophysectomized Sprague-Dawley rats evoked a diminution of plasma nonesterified fatty acids (NEFA) at 30 and 60 min. These effects were clearly distinct from the commonly observed elevation at 2–6 hr. Hypoglycemia and hypoaminoacidemia were associated temporally with the decline in plasma NEFA, Epididymal fat pads at 6 hr showed increased relative water content, as indirect evidence of intense lipid mobilization. Subtotal (95 %) pancreatectomy 3–5 days prior to removal of the hypophysis failed to prevent the 1 hr reduction of plasma NEFA in response to GH. A dose of ACTH 3 times greater than that calculated as a maximum contaminant in the larger of the GH doses used failed to elicit the 1 hr NEFA decline. The acute diminution of plasma NEFA strongly suggests, from temporal relations alone, that the adipokinetic response is not a primary effect of GH. (Endocrinology 76: 665, 1965)