Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH
Lanostane triterpenoids from Ganoderma lucidum and their inhibitory effects against FAAH
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DOI：
10.1016/j.phytochem.2022.113339
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发表时间：
2022-08-12
期刊：
影响因子：
3.8
通讯作者：
Wang, Chao
中科院分区：
文献类型：
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作者：
Li, Da-Wei;Liu, Min;Wang, Chao
灵芝是一种著名的食药用真菌。通过对灵芝子实体乙醇提取物的生物活性植物化学研究，发现灵芝子实体乙醇提取物中含有多种活性成分。从灵芝中分离出29种三萜类化合物，包括11种以前未描述的三萜类化合物，并基于光谱数据对其进行了表征。发现所有三萜对脂肪酸酰胺水解酶（FAAH）的抑制作用在100 μ M时在30-60%的范围内。灵芝酸甲酯A对FAAH的抑制活性最强（61%）。此外，所有化合物对LOVO和MCF-7人癌细胞均无细胞毒性。因此，本研究提供了有关G.灵芝作为治疗神经炎症的功能性食品或药物补充剂。
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 mu M. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all com-pounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study pro-vides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.