Antioxidant properties of carvedilol and metoprolol in heart failure: A double-blind randomized controlled trial
Antioxidant properties of carvedilol and metoprolol in heart failure: A double-blind randomized controlled trial
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DOI：
10.1097/00005344-200101000-00006
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发表时间：
2001-01-01
影响因子：
3
通讯作者：
Sanderson, JE
中科院分区：
文献类型：
--
作者：
Arumanayagam, M;Chan, S;Sanderson, JE
动物和人体研究表明，卡维地洛与其他β受体阻滞剂相比具有显著的抗氧化特性。本研究的目的是确定这些抗氧化作用是否在心力衰竭患者中可检测到，并将卡维地洛与选择性β受体阻滞剂美托洛尔进行比较。24例慢性心力衰竭患者在一所大学教学医院门诊随机接受卡维地洛或美托洛尔治疗12周。血压，心率，运动耐量，左心室射血分数，血浆总抗氧化状态，红细胞超氧化物歧化酶，谷胱甘肽过氧化物酶活性测定在基线和每4周，直到12周。结果表明，卡维地洛治疗12周后，红细胞超氧化物歧化酶和谷胱甘肽过氧化物酶显着降低，而美托洛尔没有显着的效果，虽然在短期内的临床改善是类似的两种药物。因此，卡维地洛除了改善心力衰竭的症状外，还具有显著的抗氧化特性。目前尚不清楚这一额外措施是否会影响长期结局。
Animal and human studies have shown that carvedilol has significant antioxidant properties compared with other beta -blockers. The objective of this study was to determine if these antioxidant effects: are detectable in patients with heart failure and to compare carvedilol with the selective beta -blocker metoprolol. Twenty-four patients with chronic heart failure were randomly assigned to receive either carvedilol or metoprolol in a double-blind control trial for 12 weeks in a University teaching hospital clinic. Blood pressure, heart rate, exercise tolerance, left ventricular ejection fraction, plasma total antioxidant status, erythrocyte superoxide dismutase, and glutathione peroxidase activities were determined at baseline and every 4 weeks up to 12 weeks. The results showed that erythrocyte superoxide dismutase and glutathione peroxidase were significantly reduced in carvedilol treated patients after 12 weeks of therapy, whereas metoprolol had no significant effect, although the clinical improvement over the short-term was similar with both drugs. Thus carvedilol, in addition to improving symptoms in heart failure, also possesses significant antioxidant properties. Whether this additional action influences long-term outcome is at present unknown.