Healing of Full-Thickness Murine Skin Wounds Containing Nanofibers Using Splints for Efficient Reepithelialization and to Avoid Contracture.

Healing of Full-Thickness Murine Skin Wounds Containing Nanofibers Using Splints for Efficient Reepithelialization and to Avoid Contracture.
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使用夹板治愈含有纳米纤维的全层小鼠皮肤伤口,以实现有效的上皮再生并避免挛缩。

DOI:
10.1007/978-1-0716-0655-1_10
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发表时间:
2020
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Ganguli-Indra,Gitali
Ganguli-Indra,Gitali
中科院分区:
--
文献类型:
--
作者:
Bhattacharya,Nilika;Indra,ArupK;Ganguli-Indra,Gitali

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创面愈合过程是多种细胞类型协同作用的结果,是一系列作用的结果。动态的一系列事件构成了伤口愈合的每个重叠阶段,而不是离散的阶段,这增加了它的复杂性和理解它的必要性。小鼠(通过伤口收缩)和人类(通过再上皮化)伤口愈合的不同机制提出了建立一个接近于人类伤口愈合的模型的必要性,因此小鼠切除伤口夹板模型的适用性就来了。硅胶夹板的使用已经证明了它们的有效性,通过防止愈合过程中的收缩,它们恰如其分地类似于人类再上皮化介导的伤口愈合。通过持续释放促进伤口闭合的因子/分子,基于纳米纤维的伤口愈合治疗日益流行,可以与这一模型相结合,以更人性化的方式确定其在伤口管理中的有效性。
Wound healing process is the outcome of a series of actions and combined with collaborative process involving concerted efforts of multiple cell types. The dynamic series of events constituting each of these overlapping rather than discrete stages of wound healing increases its complexity and the necessity to understand it. The contrasting mechanisms of wound healing employed by mouse (via wound contraction) and humans (via reepithelialization) puts forth the need of a model closely mimicking human wound-healing and hence comes the applicability of the mouse excisional wound splinting model. Use of silicone-based splints has demonstrated their effectiveness in aptly resembling the human reepithelialization mediated wound healing by preventing contraction during healing. The rising popularity of nanofiber-based treatments for wound healing through sustained release of factors/molecules promoting wound closure can be potentially implemented in association with this model to determine its efficacy in wound management in a more humanized way.
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