Randomized trial of nicotine lozenges and phone counseling for smokeless tobacco cessation.
Randomized trial of nicotine lozenges and phone counseling for smokeless tobacco cessation.
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尼古丁含片和无烟烟草戒烟电话咨询的随机试验。
DOI：
10.1093/ntr/ntu145
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Seeley,JohnR
中科院分区：
文献类型：
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作者：
Severson,HerbertH;Danaher,BrianG;Ebbert,JonO;vanMeter,Nora;Lichtenstein,Edward;Widdop,Chris;Crowley,Ryann;Akers,Laura;Seeley,JohnR
简介专门为想要戒烟的无烟烟草 (ST) 使用者制定的治疗方案相对较少。他们的结果表明自助材料、电话咨询和尼古丁含片是有效的。这项研究首次直接检验了电话咨询和含片的单独和综合效果。方法我们在线招募了 ST 用户（N = 1067），并将他们随机分配到 3 个条件之一：（a）含片组（n = 356），他们邮寄 4 毫克尼古丁含片； (b) 教练电话小组（n = 354），为他们提供了 3 次教练电话； (c) 菱形+教练电话组（N = 357），他们同时收到菱形和教练电话。此外，所有参与者都收到了邮寄的自助材料。随机分组后 3 个月和 6 个月对自我报告的戒烟情况进行评估。结果 在 3 个月、6 个月以及 3 个月和 6 个月（重复点患病率）时对所有戒烟情况进行完整病例分析和意向治疗 (ITT) 分析。 ITT 分析显示了高度相似的结果：含片+教练电话条件在鼓励戒烟方面比含片组或教练电话组显着更成功，两者没有差异。结论与单独干预相比，尼古丁含片和电话咨询相结合显着提高了戒烟率，而教练电话和含片是相当的。该研究证实了自助无烟烟草戒烟干预措施的高戒烟率，并为向无烟烟草使用者提供烟草治疗提供了指导。
IntroductionRelatively few treatment programs have been developed specifically for smokeless tobacco (ST) users who want to quit. Their results suggest that self-help materials, telephone counseling, and nicotine lozenges are efficacious. This study provides the first direct examination of the separate and combined effects of telephone counseling and lozenges.MethodsWe recruited ST users online (N = 1067) and randomly assigned them to 1 of 3 conditions: (a) a lozenge group (n= 356), who were mailed 4-mg nicotine lozenges; (b) a coach calls group (n= 354), who were offered 3 coaching phone calls; or (c) a lozenge + coach calls group (N= 357), who received both lozenges and coaching calls. Additionally, all participants were mailed self-help materials. Self-reported tobacco abstinence was assessed at 3 and 6 months after randomization.ResultsComplete-case and intention-to-treat (ITT) analyses for all tobacco abstinence were performed at 3 months, 6 months, and both 3 and 6 months (repeated point prevalence). ITT analyses revealed a highly similar result: the lozenge + coach calls condition was significantly more successful in encouraging tobacco abstinence than either the lozenge group or the coach calls group, which did not differ.ConclusionsCombining nicotine lozenges and phone counseling significantly increased tobacco abstinence rates compared with either intervention alone, whereas coach calls and lozenges were equivalent. The study confirms the high tobacco abstinence rates for self-help ST cessation interventions and offers guidance to providing tobacco treatment to ST users.