PATTERN OF SERUM-PROTEIN GENE-EXPRESSION IN MOUSE VISCERAL YOLK-SAC AND FETAL LIVER
PATTERN OF SERUM-PROTEIN GENE-EXPRESSION IN MOUSE VISCERAL YOLK-SAC AND FETAL LIVER
复制标题
DOI：
10.1002/j.1460-2075.1984.tb02062.x
复制
发表时间：
1984-01-01
期刊：
影响因子：
11.4
通讯作者：
HASTIE, ND
中科院分区：
文献类型：
--
作者：
MEEHAN, RR;BARLOW, DP;HASTIE, ND
Molecular hybridization shows that the mRNA for albumin, transferrin, apolipoprotein-A1 and .alpha.1-antitrypsin are expressed at high levels in mouse visceral yolk sac. The mRNA for contrapsin (a plasma protease inhibitor) and the major urinary proteins (MUP) are not detected in the visceral yolk sac at any stage of embryonic development. Contrapsin and MUP mRNA both appear late in liver development. These differences in expression suggest that the visceral yolk sac is more similar to the fetal than adult mouse liver in its pattern of gene expression. The developmental time course of expression of these mRNA is different between the fetal liver and the yolk sac. Evidence is also presented that the visceral yolk sac synthesizes and secretes other apolipoproteins in addition to apolipoprotein-A1. The visceral yolk sac and fetal liver, 2 tissues with different embyrological lineages, may perform similar functions but are independently programmed for expression of the same set of serum protein genes.
