Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up
Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up
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DOI：
10.1038/sj.ijo.0801251
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发表时间：
2000-07-01
影响因子：
4.9
通讯作者：
Tremblay, A
中科院分区：
文献类型：
--
作者：
Doucet, E;Imbeault, P;Tremblay, A
方法：17名受试者(男10名，女7名)参加了为期15周的减肥计划，其中包括药物治疗(芬氟拉明60 mg/d)或安慰剂加能量限制(-2930 kJ/d；阶段1)，然后进行18周的低脂饮食-运动随访(阶段2)。受试者在试验前、试验后和试验2后分别给予标准化早餐，并在试验前、试验后0、10、20、30、40、50和60min填写VAS。分别在餐前、餐后0分钟、30分钟和60分钟采集血样，分析血糖和胰岛素。结果：在第一阶段后，男性和女性的空腹食欲、饥饿感和预期食物消耗量(PFC)均有增加，第二阶段后的增加幅度更大。在禁食状态下，女性进食欲望的变化(r=0.76；P<；0.05)和PFC的变化(r=0.82；P<；0.05)与第一阶段结束时皮质醇的变化呈正相关。在对阶段1的反应中，男性的饥饿变化(r=0.64；P<；0.05)和进食欲望(r=0.67；P<；0.05)与空腹血浆皮质醇的变化之间存在统计学上的相关性。在第二阶段中，对基础食欲(r=0.68 P<；0.05)、饱腹感(r=-0.78，P<；0.05)和PFC(r=0.91，P<；0.01)变化最一致的预测因子是男性空腹皮质醇的变化。在第二阶段，男性的饱腹感变化也与空腹瘦素的变化相关(r=0.68；P<；0.05)。结论：这些结果表明，男性和女性的体重减轻都伴随着基线食欲的增加，而这些食欲变化最一致的预测因素似乎是空腹血浆皮质醇的变化。
OBJECTIVE: The aim of the present study was to determine the impact of weight loss on appetite as measured by visual analog scale (VAS).METHODS: Seventeen subjects (10 men and seven women) took part in a 15 week weight loss program which consisted of drug therapy (fenfluramine 60 mg/day) or placebo coupled to an energy restriction (-2930 kJ/day; phase 1) followed by an 18 week low-fat diet-exercise follow-up (phase 2). Subjects were given a standardized breakfast before and after phase 1 as well as after phase 2. Individuals were asked to fill out VAS before and at 0, 10, 20, 30, 40, 50 and 60 min after this test meal. Blood samples were drawn before the meal and at 0, 30 and 60 min postprandially and analyzed for glucose and insulin. Easting plasma cortisol and leptin were also determined.RESULTS: An increase in the fasting desire to eat, hunger and prospective food consumption (PFC) was observed after phase 1 and to an even greater extent after phase 2 in both men and women. In the fasting state, positive correlations were observed between changes in the desire to eat (r = 0.76; P < 0.05) as well as changes of PFC (r = 0.82; P < 0.05) and changes in cortisol at the end of phase 1 for women. In response to phase 1, statistically significant correlations were found between changes of hunger (r = 0.64; P < 0.05) and desire to eat (r = 0.67; P < 0.05) as measured by AUC in response to the meal and changes of fasting plasma cortisol in men. The most consistent predictor of changes of baseline desire to eat (r = 0.68 P < 0.05), fullness (r = -0.78, P < 0.05) and PFC (r = 0.91, P < 0.01) during phase 2 was the change in fasting cortisol in men. Changes of fullness were also associated with changes of fasting leptin in men (r = 0.68; P < 0.05) during phase 2.CONCLUSION: These results suggest that weight loss is accompanied by an increase of baseline appetite in both men and women and that the most consistent predictor of these changes in appetite seems to be changes in fasting plasma cortisor.