Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer.
Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer.
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基于脐带血自然杀伤细胞的癌症免疫疗法
DOI：
10.3389/fimmu.2020.584099
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发表时间：
2020
影响因子：
7.3
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Zhao X;Cai L;Hu Y;Wang H
自然杀伤（NK）细胞是先天免疫细胞的主要组成部分，在抗癌免疫中起着至关重要的作用。NK细胞可以非特异性地杀伤靶细胞，并且它们对靶细胞的识别不受主要组织相容性复合体的限制。NK细胞也独立于抗体和先前的激活而对抗肿瘤细胞。值得注意的是，脐带血（UCB）是NK细胞的丰富来源。基于UCB衍生NK细胞的免疫疗法正在得到越来越多的研究，并且这些研究正在产生令人鼓舞的结果。近年来，未修饰和修饰的脐血源性NK细胞已被成功开发用于对抗肿瘤细胞。因此，基于UCB衍生的NK细胞的免疫疗法是未来治疗癌症的潜在策略。本文就脐血NK细胞的生物学特性及其在抗肿瘤免疫治疗中的应用前景进行综述，包括最新的临床前和临床研究进展。
Natural killer (NK) cells are a predominant part of innate immune cells and play a crucial role in anti-cancer immunity. NK cells can kill target cells nonspecifically, and their recognition of target cells is not restricted by the major histocompatibility complex. NK cells also fight against tumor cells independently of antibodies and prior activation. Of note, umbilical cord blood (UCB) is a rich source of NK cells. Immunotherapies based on UCB-derived NK cells are becoming increasingly researched, and the investigations are producing encouraging results. In recent years, non-modified and modified UCB-derived NK cells have been successfully developed to fight against tumor cells. Herein, UCB-derived NK cell-based immunotherapy is a potential strategy for the treatment of cancer in the future. In this review, we focus on discussing the biological characteristics of UCB-derived NK cells and their application prospects in anti-tumor immunotherapy, including the latest preclinical and clinical researches.
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影响因子：
7.3
作者：
Easom NJW;Stegmann KA;Swadling L;Pallett LJ;Burton AR;Odera D;Schmidt N;Huang WC;Fusai G;Davidson B;Maini MK
通讯作者：
Maini MK
影响因子：
11.2
作者：
Chang, Yu-Hsiang;Connolly, John;Campana, Dario
通讯作者：
Campana, Dario
影响因子：
4.6
作者：
Herrera, L.;Santos, S.;Eguizabal, C.
通讯作者：
Eguizabal, C.
影响因子：
64.5
作者：
André P;Denis C;Soulas C;Bourbon-Caillet C;Lopez J;Arnoux T;Bléry M;Bonnafous C;Gauthier L;Morel A;Rossi B;Remark R;Breso V;Bonnet E;Habif G;Guia S;Lalanne AI;Hoffmann C;Lantz O;Fayette J;Boyer-Chammard A;Zerbib R;Dodion P;Ghadially H;Jure-Kunkel M;Morel Y;Herbst R;Narni-Mancinelli E;Cohen RB;Vivier E
通讯作者：
Vivier E
影响因子：
15.9
作者：
Finney, Olivia C.;Brakke, Hannah;Jensen, Michael C.
通讯作者：
Jensen, Michael C.