IL‐4 and a glucocorticoid up‐regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV‐1 replication
IL‐4 and a glucocorticoid up‐regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV‐1 replication
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IL-4 和糖皮质激素上调人 CD4+ T 淋巴细胞上的 CXCR4 表达并增强 HIV-1 复制
DOI：
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发表时间：
1998
影响因子：
5.5
通讯作者：
K. Matsushima
中科院分区：
文献类型：
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作者：
Jianbin Wang;A. Harada;S. Matsushita;S. Matsumi;Yi Zhang;T. Shioda;Y. Nagai;K. Matsushima
CXCR4 是感染 CD4+ T 淋巴细胞 T 向性 HIV-1 株所需的关键辅助受体。因此研究了该趋化因子受体的调节。 Th2 极化细胞比 Th1 细胞表达更多的 CXCR4。在一组细胞因子和兴奋剂中，Th2 型细胞因子白介素-4 (IL-4) 在 16 小时内选择性上调 CXCR4 的 mRNA 水平和表面蛋白表达。此外，CXCR4 也被糖皮质激素地塞米松上调。这些处理过的细胞在跨内皮迁移测定中对特定 CXCR4 配体 SDF-1α 的反应变得更加敏感。此外，CXCR4 的上调还与人类 CD4+ T 淋巴细胞中 HIV 复制的增强有关。这项研究表明，通过几种免疫调节剂、IL-4 和糖皮质激素上调 CXCR4，增强了 CD4+ T 淋巴细胞的 T 向性 HIV-1 感染。这些发现可能解释了艾滋病进展过程中 Th2 占主导地位时向 T 向性 HIV-1 的转变。 J.洛科克。生物。 64：642–649； 1998.
CXCR4 is a key co‐receptor required for the infection of T‐tropic HIV‐1 strain of CD4+ T lymphocytes. The regulation of this chemokine receptor was therefore studied. Th2 polarized cells expressed more CXCR4 than Th1 cells. Among a panel of cytokines and stimulants, a Th2 type cytokine interleukin‐4 (IL‐4) selectively up‐regulated the mRNA level as well as surface protein expression of CXCR4 within 16 h. In addition, CXCR4 was also up‐regulated by a glucocorticoid, dexamethasone. These treated cells became more responsive in transendothelial migration assays to the specific CXCR4 ligand, SDF‐1α. Furthermore, up‐regulation of CXCR4 was also associated with the enhancement of HIV replication in human CD4+ T lymphocytes. This study indicates the enhanced T‐tropic HIV‐1 infection to CD4+ T lymphocytes through up‐regulation of CXCR4 by several immunomodulating agents, IL‐4, and a glucocorticoid. These findings may explain the shift to T‐tropic HIV‐1 dominance during AIDS progression when Th2 comes to predominate. J. Leukoc. Biol. 64: 642–649; 1998.
影响因子：
3.8
作者：
E. Berger
通讯作者：
E. Berger