Phospholipase A2 regulation of arachidonic acid mobilization
Phospholipase A2 regulation of arachidonic acid mobilization
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DOI：
10.1016/s0014-5793(02)03413-0
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发表时间：
2002-10-30
期刊：
影响因子：
3.5
通讯作者：
Dennis, EA
中科院分区：
文献类型：
--
作者：
Balsinde, J;Winstead, MV;Dennis, EA
磷脂酶A（2）（PLA（2））是一个不断发展的脂肪分解酶超家族，迄今为止，在哺乳动物中至少发现了19种不同的酶。鉴于其在脂质信号传导中的作用和其在多种炎性病症中的参与，这类酶作为药理学靶标引起了相当大的兴趣。PLA（2）s水解细胞磷脂的sn-2酯键，产生游离脂肪酸和溶血磷脂，两者都是脂质信号分子。所产生的游离脂肪酸通常是花生四烯酸（AA，5，8，11，14-二十碳四烯酸），其是有效炎症介质的类二十烷酸家族的前体，所述炎症介质包括白细胞生成素、血栓烷、白三烯和脂氧素。多种PLA（2）酶在细胞内和细胞周围活跃，这些酶在AA释放中具有不同但相互关联的作用。(C)2002年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
Phospholipase A(2) (PLA(2)) constitutes a growing superfamily of lipolytic enzymes, and to date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has attracted considerable interest as a pharmacological target in view of its role in lipid signaling and its involvement in a variety of inflammatory conditions. PLA(2)s hydrolyze the sn-2 ester bond of cellular phospholipids, producing a free fatty acid and a lysophospholipid, both of which are lipid signaling molecules. The free fatty acid produced is frequently arachidonic acid (AA, 5,8,11,14-eicosatetraenoic acid), the precursor of the eicosanoid family of potent inflammatory mediators that includes prostaglandins, thromboxanes, leukotrienes and lipoxins. Multiple PLA(2) enzymes are active within and surrounding the cell and these enzymes have distinct, but interconnected roles in AA release.(C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.