Predicting Peritoneal Dissemination of Gastric Cancer in the Era of Precision Medicine: Molecular Characterization and Biomarkers.
Predicting Peritoneal Dissemination of Gastric Cancer in the Era of Precision Medicine: Molecular Characterization and Biomarkers.
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精准医学时代预测胃癌腹膜播散：分子特征和生物标志物。
DOI：
10.3390/cancers12082236
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发表时间：
2020-08-10
期刊：
影响因子：
5.2
通讯作者：
Teng L
中科院分区：
文献类型：
--
作者：
Chen Y;Zhou Q;Wang H;Zhuo W;Ding Y;Lu J;Wu G;Xu N;Teng L
Gastric cancer (GC) is a leading cause of worldwide cancer-related death. Being a highly heterogeneous disease, the current treatment of GC has been suboptimal due to the lack of subtype-dependent therapies. Peritoneal dissemination (PD) is a common pattern of GC metastasis associated with poor prognosis. Therefore, it is urgently necessary to identify patients at high risk of PD. PD is found to be associated with Lauren diffuse type GC. Molecular profiling of GC, especially diffuse type GC, has been utilized to identify molecular alterations and has given rise to various molecular classifications, shedding light on the underlying mechanism of PD and enabling identification of patients at higher PD risk. In addition, a series of diagnositc and prognostic biomarkers of PD from serum, peritoneal lavages and primary GCs have been reported. This comprehensive review summarizes findings on the multi-omic characteristics of diffuse type GC, the clinical significance of updating molecular classifications of GC in association with PD risk and research advances in PD-associated biomarkers.
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影响因子：
2.5
作者：
Bautista MC;Jiang SF;Armstrong MA;Postlethwaite D;Li D
通讯作者：
Li D
影响因子：
7.4
作者：
Emoto, Shigenobu;Ishigami, Hironori;Kitayama, Joji
通讯作者：
Kitayama, Joji
影响因子：
7.4
作者：
Dalal, Kimberly Moore;Woo, Yanghee;Coit, Daniel G.
通讯作者：
Coit, Daniel G.
开发和验证个体化列线图以识别晚期胃癌患者隐匿性腹膜转移
影响因子：
50.5
作者：
Dong, D.;Tang, L.;Ji, J-F
通讯作者：
Ji, J-F
DOI：
10.1073/pnas.1422640112
发表时间：
2015-01-27
影响因子：
11.1
作者：
Chen, Kexin;Yang, Da;Hao, Xishan
通讯作者：
Hao, Xishan