The long-term increase of baseline and reflexly augmented levels of human vagal-cardiac nervous activity induced by scopolamine.
The long-term increase of baseline and reflexly augmented levels of human vagal-cardiac nervous activity induced by scopolamine.
复制标题
东莨菪碱诱导的人类迷走神经-心脏神经活动的基线水平和反射增强水平的长期增加。
DOI：
10.1161/01.cir.71.4.797
复制
发表时间：
1985
期刊：
影响因子：
37.8
通讯作者：
Cintrón-Treviño,NM
中科院分区：
文献类型：
--
作者：
Dibner-Dunlap,ME;Eckberg,DL;Magid,NM;Cintrón-Treviño,NM
We tested the hypothesis that transdermal scopolamine increases vagal-cardiac nervous outflow over the long term in 16 healthy young men. Twenty-four hours after application of one scopolamine patch, the average RR interval was increased by 13% and the average standard deviation of the RR interval (taken as an index of the level of vagal-cardiac nervous activity) was increased by 31%. Baroreceptor-cardiac reflex responsiveness (as reflected by prolongation of RR interval provoked by graded neck suction) also was increased substantially. These findings suggest that vagal-cardiac nervous activity can be augmented pharmacologically in man on a long-term basis. Since vagal outflow influences cardiac electrical properties in an important way, these findings may have therapeutic implications.
