New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract.
New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract.
复制标题
DOI：
10.1254/jphs.09r09fm
复制
发表时间：
2010
影响因子：
3.5
通讯作者：
Satoshi Miyauchi;A. Hirasawa;A. Ichimura;Takafumi Hara;G. Tsujimoto
中科院分区：
文献类型：
--
作者：
Satoshi Miyauchi;A. Hirasawa;A. Ichimura;Takafumi Hara;G. Tsujimoto
利用人类基因组数据库，最近开发的G-蛋白偶联受体（GPCR）去乙酰化策略成功地鉴定了多种游离脂肪酸（FFA）受体。FFA已被证明可作为几种GPCR（FFAR 1、FFAR 2、FFAR 3和GPR 120）的配体。这些脂肪酸受体被认为在各种类型的生理稳态中起关键作用。FFAR 1和GPR 120被中链和长链FFA激活。相反，FFAR 2和FFAR 3被短链FFA激活。已经阐明，这四种受体在胃肠道中表达，并且作为FFA的传感器具有许多重要的作用。本文就胃肠道内受体的生理和药理作用作一综述。
Utilizing the human genome database, the recently developed G-protein-coupled receptors (GPCRs) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs). FFAs have been demonstrated to act as ligands of several GPCRs (FFAR1, FFAR2, FFAR3, and GPR120). These fatty acid receptors are proposed to play critical roles in various types of physiological homeostases. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. It has been elucidated that these four receptors are expressed in the gastrointestinal tract and have many essential roles as sensors of FFA. In this review, we summarize the physiological and pharmacological function of the receptors in the gastrointestinal tract.