The role of anaerobes in diabetic foot infections
The role of anaerobes in diabetic foot infections
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DOI：
10.1016/j.anaerobe.2015.03.009
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发表时间：
2015-08-01
期刊：
影响因子：
2.3
通讯作者：
Lipsky, Benjamin A.
中科院分区：
文献类型：
--
作者：
Charles, Patrick G. P.;Uckay, Ilker;Lipsky, Benjamin A.
糖尿病足感染（DFI）是发病的常见原因，有时甚至死亡。感染可以是单微生物或多微生物，具有多种潜在病原体。厌氧菌可能参与，特别是在更深或更慢性的伤口中，并且在使用现代分子技术（如16s PCR和焦磷酸测序）时更频繁地被识别。尚不清楚DFI中厌氧菌的存在是否导致更严重的表现，或者这些生物体是否主要是与存在更大程度的组织缺血和坏死相关的定植者。糖尿病足感染的常用经验性抗生素治疗通常是广谱的，通常对最常见的厌氧菌具有活性，如消化链球菌和拟杆菌属。充分的手术清创和必要时的足血管重建至少与抗生素的选择一样重要，以获得成功的治疗结果。(C)2015爱思唯尔有限公司版权所有。
Diabetic foot infections (DFI) are a common cause of morbidity and, on occasion, even mortality. Infection can be either mono- or polymicrobial, with a wide variety of potential pathogens. Anaerobes may be involved, particularly in wounds that are deeper or more chronic, and are more frequently identified when using modern molecular techniques, such as 16s PCR and pyrosequencing. It remains unclear whether the presence of anaerobes in DFI leads to more severe manifestations, or if these organisms are largely colonizers associated with the presence of greater degrees of tissue ischemia and necrosis. Commonly used empiric antibiotic therapy for diabetic foot infections is generally broad-spectrum and usually has activity against the most frequently identified anaerobes, such as Peptostreptococcus and Bacteroides species. Adequate surgical debridement and, when needed, foot revascularization may be at least as important as the choice of antibiotic to achieve a successful treatment outcome. (C) 2015 Elsevier Ltd. All rights reserved.