Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth A Scientific the
Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth A Scientific the
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心血管疾病的非传统危险因素和生物标志物：青少年的机制、研究和临床考虑
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通讯作者：
Hyun Chul Lee
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作者：
E. Kang;S. Y. Park;H. Kim;C. Ahn;M. Nam;B. Cha;Sungkil Lim;K. Kim;Hyun Chul Lee
—儿童肥胖患病率和严重程度的迅速增加可能会降低全世界心血管疾病的发病年龄并增加其发病率。了解心血管疾病的病理生理学和改善临床管理涉及新的危险因素和生物标志物的知识。目前正在研究这些新的生物因素在儿童时期的临床和机制作用。本科学声明的目标是介绍与儿童和青少年相关的心血管疾病非传统危险因素的现有知识和理论框架，描述现有实验和临床证据的相关性和重要性以及与儿科人群非传统危险因素相关的治疗意义，并促进进一步研究，以开发有效和可靠的方法来识别和验证新的危险因素，这将有助于儿科人群心血管疾病的临床评估和预测。尽管一些生物标志物前景广阔，但在使用非传统危险因素来识别和降低儿童和青少年心血管疾病风险之前，还需要进行大量研究。 （流通。2011；123：2749-2769。）
—The rapid increase in the prevalence and severity of obesity in children is likely to lower the age of onset and increase the incidence of cardiovascular disease worldwide. Understanding the pathophysiology and improving the clinical management of cardiovascular disease involve a knowledge of novel risk factors and biomarkers. The clinical and mechanistic roles of these novel biological factors during childhood are currently being investigated. The goals of this scientific statement are to present the existing knowledge and theoretical framework of nontraditional risk factors for cardiovascular disease as they relate to children and adolescents, to describe the relevance and weight of available experimental and clinical evidence and the therapeutic implications pertaining to nontraditional risk factors in the pediatric population, and to stimulate further research with a goal of developing valid and reliable approaches to identify and validate novel risk factors that will aid in the clinical evaluation and perhaps prediction of cardiovascular disease in the pediatric population. Although several biomarkers are promising, substantial research is required before nontraditional risk factors can be used to identify and reduce cardiovascular disease risk in children and adolescents. ( Circulation . 2011;123:2749-2769.)