Anti-androgenic activities of Ganoderma lucidum
Anti-androgenic activities of Ganoderma lucidum
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DOI：
10.1016/j.jep.2005.05.041
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发表时间：
2005-10-31
影响因子：
5.4
通讯作者：
Kondo, R
中科院分区：
文献类型：
--
作者：
Fujita, R;Liu, J;Kondo, R
本文研究了19种食用和药用蘑菇的甲醇提取物对5 α-还原酶活性的抑制作用。灵芝（Ganodermataceae）的提取物显示出最强的5 α-还原酶抑制活性。灵芝子实体或其提取物的处理显著抑制睾丸激素诱导的去势大鼠腹侧前列腺的生长。结果表明，灵芝可能是治疗良性前列腺增生症（BPH）的有效成分。(C)2005爱思唯尔爱尔兰有限公司保留所有权利。
The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5 alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5 alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH). (C) 2005 Elsevier Ireland Ltd. All rights reserved.