Novel therapies for the treatment of advanced prostate cancer.
Novel therapies for the treatment of advanced prostate cancer.
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DOI：
10.1007/s11864-012-0222-4
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发表时间：
2013-03
影响因子：
4.3
通讯作者：
Armstrong, A. J.
中科院分区：
文献类型：
--
作者：
Clarke, J. M.;Armstrong, A. J.
关键词：
近年来，男性转移性去势抵抗性前列腺癌（CRPC）的治疗在许多方面取得了巨大成功，包括新型化疗药物、免疫疗法、骨微环境靶向药物和激素疗法。目前，许多治疗晚期前列腺癌的药物正处于早期临床试验阶段。这些新疗法针对前列腺肿瘤生物学的几个领域，包括雄激素信号和生物合成的上调、关键的致癌细胞内通路、表观遗传改变和癌症免疫学。重要的是，前列腺癌基因组的特征提供了开发保守遗传改变的潜力，这可能会增加这些靶向治疗的疗效。迫切需要预测和预后的生物标志物，以最大限度地提高这些有前景的前列腺癌新治疗方案的治疗效果和安全性。
Opinion statement In recent years, great success has been achieved on many fronts in the treatment of men with metastatic castration-resistant prostate cancer (CRPC), including novel chemotherapeutics, immunotherapies, bone microenvironment-targeted agents, and hormonal therapies. Numerous agents are currently in early-phase clinical trial development for the treatment of advanced prostate cancer. These novel therapies target several areas of prostate tumor biology, including the upregulation of androgen signaling and biosynthesis, critical oncogenic intracellular pathways, epigenetic alterations, and cancer immunology. Importantly, the characterization of the prostate cancer genome offers the potential to exploit conserved genetic alterations, which may increase the efficacy of these targeted therapies. Predictive and prognostic biomarkers are urgently needed to maximize therapeutic efficacy and safety of these promising new treatments options in prostate cancer.
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影响因子：
82.9
作者：
Chen, CD;Welsbie, DS;Sawyers, CL
通讯作者：
Sawyers, CL
影响因子：
6.2
作者：
Araujo JC;Mathew P;Armstrong AJ;Braud EL;Posadas E;Lonberg M;Gallick GE;Trudel GC;Paliwal P;Agrawal S;Logothetis CJ
通讯作者：
Logothetis CJ
影响因子：
2.7
作者：
Bruno RD;Vasaitis TS;Gediya LK;Purushottamachar P;Godbole AM;Ates-Alagoz Z;Brodie AM;Njar VC
通讯作者：
Njar VC
DOI：
10.1158/1078-0432.ccr-09-0265
发表时间：
2009-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dewan MZ;Galloway AE;Kawashima N;Dewyngaert JK;Babb JS;Formenti SC;Demaria S
通讯作者：
Demaria S
影响因子：
50.3
作者：
Domingo-Domenech J;Vidal SJ;Rodriguez-Bravo V;Castillo-Martin M;Quinn SA;Rodriguez-Barrueco R;Bonal DM;Charytonowicz E;Gladoun N;de la Iglesia-Vicente J;Petrylak DP;Benson MC;Silva JM;Cordon-Cardo C
通讯作者：
Cordon-Cardo C