Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM.
Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM.
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用 2,5-AM 治疗的大鼠饮食行为与肝脏腺嘌呤核苷酸之间的时间关系。
DOI：
10.1152/ajpregu.1998.274.3.r610
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Friedman,MI
中科院分区：
文献类型：
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作者：
Koch,JE;Ji,H;Osbakken,MD;Friedman,MI
给予果糖类似物2，5-脱水-d-甘露醇(2，5-AM)通过其在肝脏的作用而引起大鼠的进食行为。为了评估注射2，5-AM引起的肝脏ATP水平下降是否在进食反应中起作用，我们研究了给予2，5-AM的大鼠进食行为的变化与肝腺嘌呤核苷酸水平随时间的变化之间的关系。注射2，5-AM(300 mg/kg ip)后15min内，肝组织ATP含量下降，持续90min，4h后恢复至生理盐水对照组水平。在肝脏ATP水平下降后，自由进食的大鼠在2，5-AM治疗后15到45分钟内开始进食。大鼠在2，5-AM处理后1小时进食可增加摄食量，但如果在2，5-AM注射后延迟4小时进食，则进食反应减弱或消失。虽然注射2，5-AM也会改变肝脏的AMP和ADP水平，但食物摄入量的变化并不总是跟踪这些核苷酸的变化。结果支持2，5-AM的进食反应是由肝脏ATP水平下降所触发的假说。
Administration of the fructose analog 2,5-anhydro-d-mannitol (2,5-AM) elicits eating behavior in rats by its action in the liver. To evaluate whether the decrease in liver ATP levels produced by injection of 2,5-AM plays a role in the eating response, we examined the relationship between changes in eating behavior and liver adenine nucleotide levels over time in rats given 2,5-AM. Liver ATP concentrations decreased within 15 min after injection of 2,5-AM (300 mg/kg ip), remained low for up to 90 min postinjection, and returned to control (saline injection) levels by 4 h after treatment. Rats fed ad libitum initiated eating between 15 and 45 min after 2,5-AM treatment, after liver ATP levels had declined. Rats given food 1 h after 2,5-AM treatment increased food intake, but if access to food was delayed for 4 h after 2,5-AM injection the eating response was attenuated or absent. Whereas liver AMP and ADP levels were also altered by injection of 2,5-AM, changes in food intake did not consistently track changes in these nucleotides. The results support the hypothesis that the eating response to 2,5-AM is triggered by a decrease in liver ATP level.