Adiponectin levels and genotype: A potential regulator of life span in humans
Adiponectin levels and genotype: A potential regulator of life span in humans
复制标题
DOI：
10.1093/gerona/63.5.447
复制
发表时间：
2008-05-01
影响因子：
5.1
通讯作者：
Barzilai, Nir
中科院分区：
文献类型：
--
作者：
Atzmon, Gil;Pollin, Toni I.;Barzilai, Nir
尽管在许多模型中限制热量可以延长寿命，但人类的寿命被认为是受到肥胖症流行率增加的限制。脂联素是一种脂肪源性肽，对年龄相关疾病具有保护作用，因此是一个很好的长寿候选基因。我们研究了百岁老人（n = 118）、他们的后代（n = 228）和无关参与者的脂联素水平
Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants