Polymer designs to control biofilm growth on medical devices
Polymer designs to control biofilm growth on medical devices
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DOI：
10.1023/b:resb.0000040469.26208.83
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发表时间：
2003-01-01
期刊：
影响因子：
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通讯作者：
Stoodley, P.
中科院分区：
文献类型：
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作者：
Francolini, I.;Donelli, G.;Stoodley, P.
留置和临时医疗输送装置(即导管)在医院环境中的使用越来越多，为临床医生提供了管理营养、采集血液样本和输送药物的有用工具。然而，它们往往会使患者面临局部或全身感染的风险，包括血液感染和心内膜炎。微生物很容易附着在表面，并通过形成一层粘稠的生物膜来定居。与浮游细胞相比，生长在生物膜中的细菌表现出更强的抗药性。因此，这些医疗器械相关感染的抗生素治疗经常失败。分离导致微栓子的形成是另一个与生物膜相关的并发症。由于感染往往涉及更高的发病率和死亡率、延长住院时间和额外的医疗费用，在过去的20年里，已经制定了各种策略来防止植入的医疗器械上形成生物膜。在这篇文章中，我们回顾和讨论了抑制细菌在这些设备上黏附和生长的最重要的实验方法。
Indwelling and temporary medical delivery devices (i.e. catheters) are increasingly used in hospital settings, providing clinicians with useful tools to administer nutrients, draw blood samples and deliver drugs. However, they can often put patients at risk for local or systemic infections, including bloodstream infections and endocarditis. Microorganisms readily adhere to the surfaces and colonize them by forming a slimy layer of biofilm. Bacteria growing in biofilms exhibit an increased antibiotic resistance in comparison with planktonic cells. Consequently the antibiotic treatment of these medical device-associated infections frequently fails. Detechment resulting in the formation of microemboli is a further biofilm related complication. Since infections often involve increased morbidity and morality, prolonged hospitalization and additional medical costs, various strategies to prevent biofilm formation on implanted medical devices have been developed over the last two decades. In this paper we review and discuss the most significant experimental approaches to inhibit bacterial adhesion and growth on these devices.