Radiosensitivity and relative biological effectiveness based on a generalized target model.
Radiosensitivity and relative biological effectiveness based on a generalized target model.
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基于广义目标模型的放射敏感性和相对生物有效性。
DOI：
10.1093/jrr/rrw062
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发表时间：
2017-01
影响因子：
2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhao L;Wu D;Mi D;Sun Y
通过同时考虑细胞修复效应和辐射的间接效应，我们推广了传统的目标模型，使其具有线性-二次-线性特性。为了评估修复能力依赖的辐射敏感性和相对生物学效应（RBE），使用广义靶模型拟合不同类型辐射后处于G0和G1期的人胚肺成纤维细胞MRC-5的存活。拟合结果表明，广义目标模型在所考虑的剂量范围内工作良好。计算结果定性地表明，模型中的参数比值（a/V）可以表征细胞的修复能力。特别是，放射敏感性/RBE和细胞修复能力之间的显着的线性相关性，观察到不同的斜率的线性回归曲线。这些结果表明，辐射敏感性和RBE依赖于细胞的修复能力，并可以通过线性能量转移来调节。这些分析表明，广义靶区模型中的a/V比值也可用于放射治疗中的辐射损伤评估。
By considering both cellular repair effects and indirect effects of radiation, we have generalized the traditional target model, and made it have a linear–quadratic–linear characteristic. To assess the repair capacity–dependent radiosensitivity and relative biological effectiveness (RBE), the generalized target model was used to fit the survival of human normal embryonic lung fibroblast MRC-5 cells in the G0 and G1 phases after various types of radiations. The fitting results indicate that the generalized target model works well in the dose ranges considered. The resulting calculations qualitatively show that the parameter ratio (a/V) in the model could represent the cellular repair capacity. In particular, the significant linear correlations between radiosensitivity/RBE and cellular repair capacity are observed for different slopes of the linear regression curves. These results show that the radiosensitivity and RBE depend on the cellular repair capacity and can be regulated by linear energy transfer. These analyses suggest that the ratio a/V in the generalized target model can also be used for radiation damage assessment in radiotherapy.