New method of deep brain stimulation therapy with two electrodes implanted in parallel and side by side.
New method of deep brain stimulation therapy with two electrodes implanted in parallel and side by side.
复制标题
平行并排植入两个电极的深部脑刺激治疗新方法。
DOI：
10.3171/jns.2001.95.6.1075
复制
发表时间：
2001
影响因子：
4.1
通讯作者：
Kazutaka Kobayashi
中科院分区：
文献类型：
--
作者：
Takamitsu Yamamoto;Yoichi Katayama;C. Fukaya;H. Oshima;M. Kasai;Kazutaka Kobayashi
可逆性和适应性是长期治疗性脑深部电刺激（DBS）的首选特征。在这种治疗中，具有四个接触点的永久刺激电极被放置在刺激部位，并且一般来说，双极刺激由一个电极上的多对相邻接触点引起。因此，刺激部位都沿着植入电极的轨迹定位。在一例单侧严重特发性震颤患者中，作者将两个电极并排并平行植入单侧丘脑腹中间核。使用这些电极，作者不仅能够沿着电极轨迹输送电流，而且能够在平行于前连合-后连合线的方向上在两个电极之间输送电流。虽然使用所有参数和所有刺激点由两个电极中的每一个递送的单独刺激无法完全停止患者的震颤而没有不利影响，但是电流在两个电极之间通过的新刺激方法实现了震颤的完全消除而没有不利影响。借助于这种方法，可以使用两个平行和并排植入的电极，以实现最大功效并减少DBS治疗的某些情况下的副作用。
Reversibility and adaptability are preferred features of long-term therapeutic deep brain stimulation (DBS). In such therapy, a permanent stimulating electrode with four contact points is placed at the stimulation site and, generally speaking, bipolar stimulation is induced by various pairs of adjacent contact points on one electrode. The stimulation sites are thus all located along the trajectory of the implanted electrode. In a patient with unilateral severe essential tremor, the authors implanted two electrodes side by side and parallel to each other in the unilateral thalamic ventralis intermedius nucleus. Using these electrodes, the authors were able to deliver current flow not only along the electrode trajectory, but also between the two electrodes in a direction parallel to the anterior commissure-posterior commissure line. Although individual stimulations, delivered by each of the two electrodes using all parameters and all stimulation points, were unable to stop the patient's tremor completely without adverse effects, the new stimulation method, in which electrical currents passed between the two electrodes, effected complete abolition of the tremor without adverse effects. With the aid of this method, one can use two electrodes, implanted in parallel and side by side, to achieve maximum efficacy and to reduce adverse effects in some instances of DBS therapy.