CHARACTERIZATION OF ROS1 CDNA FROM A HUMAN GLIOBLASTOMA CELL-LINE
CHARACTERIZATION OF ROS1 CDNA FROM A HUMAN GLIOBLASTOMA CELL-LINE
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DOI：
10.1073/pnas.87.12.4799
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发表时间：
1990-06-01
影响因子：
11.1
通讯作者：
WIGLER, M
中科院分区：
文献类型：
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作者：
BIRCHMEIER, C;ONEILL, K;WIGLER, M
我们已经从胶质母细胞瘤细胞系SW-1088中分离并鉴定了人ROS 1 cDNA。该cDNA长8.3个丝氨酸，具有编码跨膜酪氨酸特异性蛋白激酶的潜力，预测分子量为259 kDa。推定的ROS 1的胞外结构域与果蝇的sevenless基因产物的胞外结构域同源。ROS 1与其他受体型酪氨酸激酶的胞外结构域没有相似之处。ROS 1和sevenless基因产物共同定义了一个不同的跨膜酪氨酸激酶亚类。
We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarites in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.