Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases.
Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases.
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DOI：
10.2174/0929867323666161202150008
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发表时间：
2017
影响因子：
4.1
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Shang M;Sun J
维生素D是通过其受体维生素D受体(VDR)作用调节炎症、免疫反应和抑癌的重要因素。最近的研究证实了维生素D/VDR在调节宿主-细菌相互作用中的作用。益生菌是一种有益的细菌，具有支持或促进宿主生命的能力。本文就维生素D/VDR在肠道微生物群和炎症中作用的最新研究进展进行综述。我们将总结益生菌在调节维生素D/VDR和平衡肠道微生物区系方面在健康和胃肠道疾病中的证据。此外，我们还将对益生菌在预防和治疗IBD或结肠癌方面的临床应用进行综述。尽管取得了这些进展，但倡导在临床治疗中广泛使用益生菌仍然存在几个障碍。我们还将讨论在科学理解益生菌、维生素D/VDR和宿主反应方面的局限性和未来方向。
Vitamin D is an important factor in regulating inflammation, immune responses, and carcinoma inhibition via action of its receptor, vitamin D receptor (VDR). Recent studies have demonstrated the role of vitamin D/VDR in regulating host-bacterial interactions. Probiotics are beneficial bacteria with the power of supporting or favoring life on the host. In the current review, we will discuss the recent progress on the roles of vitamin D/VDR in gut microbiome and inflammation. We will summarize evidence of probiotics in modulating vitamin D/VDR and balancing gut microbiota in health and gastrointestinal diseases. Moreover, we will review the clinical application of probiotics in prevention and therapy of IBD or colon cancer. Despite of the gains, there remain several barriers to advocate broad use of probiotics in clinical therapy. We will also discuss the limits and future direction in scientific understanding of probiotics, vitamin D/VDR, and host responses.