Differences in behavior and monoamine laterality following neonatal clomipramine treatment
Differences in behavior and monoamine laterality following neonatal clomipramine treatment
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DOI：
10.1002/dev.10055
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发表时间：
2002-07-01
影响因子：
2.2
通讯作者：
Teicher, MH
中科院分区：
文献类型：
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作者：
Andersen, SL;Dumont, NL;Teicher, MH
产后8至21日龄用氯丙咪嗪（15毫克/公斤，每日两次）治疗产生的动物模型具有许多抑郁症的行为特征。在这项研究中，我们研究了这种早期治疗对成年动物的持久行为和神经化学影响。运动活动在氯丙拉明处理的男性，而不是女性，相对于车辆处理的受试者增加。在暴露于氯丙帕明的成年人中，也观察到在高焦虑迷宫中焦虑样行为的增加，但没有发现性别差异。氯米帕明处理的动物在右侧血清素水平较低的边缘区域单胺的偏侧性发生变化，而车辆处理的动物在左侧血清素水平较低。多巴胺含量的偏侧化表现出相同的模式。这种单胺能含量的下降与临床研究一致，证明了重度抑郁患者血清素的减少以及功能侧化的改变。(C) 2002 Wiley期刊有限公司
Postnatal treatment between 8 to 21 days of age with clomipramine (15 mg/kg, twice daily) produces an animal model that has many of the behavioral hallmarks of depression. In this study, we investigated the enduring behavioral and neurochemical effects of this early, treatment in adult animals. Locomotor actitity was increased in cloinipramine-treated males, but not females, relative to vehicle-treated subjects. Increases in anxiety-like behavior in the elevated phis maze also were observed in clomipramine-exposed adults, but no sex differences were detected. Clomipramine-treated animals had shifts in the laterality of monoamines in limbic regions with lower serotonin levels on the right side while vehicle-treated animals had lower serotonin on the left side. The lateralization of dopamine content demonstrated the same pattern. This decline in monoaminergic content is consistent with clinical studies demonstrating decrements in serotonin as well as alterations in the lateralization of function in individuals with major depressive order. (C) 2002 Wiley Periodicals, Inc.