InAs quantum well Hall devices for room-temperature detection of single magnetic biomolecular labels
InAs quantum well Hall devices for room-temperature detection of single magnetic biomolecular labels
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DOI：
10.1063/1.2767385
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发表时间：
2007-08-01
影响因子：
3.2
通讯作者：
Sullivan, Gerard J.
中科院分区：
文献类型：
--
作者：
Mihajlovic, Goran;Xiong, Peng;Sullivan, Gerard J.
利用含有二维电子气体的InAs/AlSb量子阱半导体异质结构制备了横向宽度接近1 μ m的霍尔传感器。通过霍尔效应和电子噪声测量以及解析计算对器件的室温特性进行了检验。在20 Hz ~ 1.6 kHz的低频范围内，噪声等效磁场分辨率受到I - If和22 ~ 3.5 μ T /根Hz的产生复合噪声的限制。相应的噪声等效磁矩分辨率在接近700hz时达到10(6)mu(B)/根Hz，在更高频率时甚至更低。采用相敏测量技术，对单个直径1.2 μ m、适用于生物应用的微球进行检测，信噪比接近33.3 dB；对6个250 nm微球进行检测，信噪比接近2.3 dB /微球。该工作证明了InAs量子阱霍尔器件在单磁性生物分子标记的高灵敏度检测中的有效性。(c) 2007年美国物理学会。
Hall sensors with cross width of similar to 1 mu m were fabricated from InAs/AlSb quantum well semiconductor heterostructures containing two-dimensional electron gas. The room-temperature device characteristics were examined by Hall effect and electronic noise measurements along with analytical calculations. In the low-frequency range, from 20 Hz to 1.6 kHz, the noise-equivalent magnetic field resolution was found to be limited by I If and generation-recombination noise from 22 to 3.5 mu T / root Hz. The corresponding noise-equivalent magnetic moment resolution reached 10(6)mu(B)/ root Hz at similar to 700 Hz and was even lower at higher frequencies. Using a phase-sensitive measurement technique, detection of a single 1.2 mu m diameter bead, suitable for biological applications, was achieved with a signal to noise ratio of similar to 33.3 dB, as well as detection of six 250 nm beads with a signal to noise of similar to 2.3 dB per bead. The work demonstrates the efficacy of InAs quantum well Hall devices for application in high sensitivity detection of single magnetic biomolecular labels. (c) 2007 American Institute of Physics.