Preventing ptosis after botulinum treatment.
Preventing ptosis after botulinum treatment.
复制标题
肉毒杆菌治疗后预防上睑下垂。
DOI：
10.1097/00002341-199706000-00002
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发表时间：
1997
影响因子：
2
通讯作者：
Scott,AB
中科院分区：
文献类型：
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作者：
Scott,AB
在一系列的33名眼睑痉挛患者中，这些患者在治疗性A型肉毒杆菌毒素（Botox：Allergan，Inc.，Irvine，CA，USA）注射后，我们在注射毒素后施用41次人肉毒杆菌免疫球蛋白（IG）注射，以测试IG注射的剂量和时间及其在限制或避免上睑下垂方面的有效性。当在4小时内注射到同一组织部位时，每单位肉毒杆菌毒素3.2 × 10-3国际单位（IU）的IG剂量可有效阻断毒素作用。在19名患者中，将1.6 × 10-2至3.2 × 10-2的IG剂量注入具有更频繁的上睑下垂的眼提肌，使上睑下垂的发生率降低至11%。对侧（对照）眼的上睑下垂发生率为37%。IG或其注射未发生眼眶出血或其他不良反应。
In a series of 33 blepharospasm patients who had the side effect of ptosis following therapeutic botulinum toxin type A (Botox: Allergan, Inc., Irvine, CA, USA) injection, we administered 41 injections of human botulinum immune globulin (IG) following injections of the toxin to test the dosage and timing of IG injection and its effectiveness in limiting or avoiding ptosis. An IG dose of 3.2 10-3 international units (IU) per unit of Botox was effective in blocking toxin effect when injected into the same tissue site within 4 hours. An IG dose of 1.6 10-2 to 3.2 10-2 into the levator of the eye having more frequent ptosis in 19 patients reduced the incidence of ptosis to 11%. The fellow (control) eye had a ptosis incidence of 37%. No orbital hemorrhage or other adverse effect occurred from the IG or its injection.