Chorda tympani responses in two inbred strains of mice with different taste preferences
Chorda tympani responses in two inbred strains of mice with different taste preferences
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DOI：
10.1016/s0031-9384(99)00071-2
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发表时间：
1999-08-15
影响因子：
2.9
通讯作者：
Blizard, DA
中科院分区：
文献类型：
--
作者：
Frank, ME;Blizard, DA
行为研究表明，近交系小鼠（Mus musculus）品系的味觉系统存在显着差异：C57BL/6J (B6) 和 DBA/2J (D2)。为了了解行为差异的生物学基础，我们记录了全神经鼓索对味觉溶液的反应，并将结果与未剥夺小鼠摄入类似溶液的结果进行了比较。刺激包括由 0.1 M 氯化钠、0.3 M 蔗糖、10 mM 糖精钠、3 mM 盐酸和 3 mM 盐酸奎宁组成的测试系列，以及相同物质的浓度系列。 B6 小鼠中由蔗糖、糖精或 NaCl 引起的鼓索神经活动高于 D2 小鼠； B6 小鼠对蔗糖的神经阈值较低，但 D2 小鼠对 HCl 和奎宁的神经阈值较低。 B6小鼠比D2小鼠摄入更多的蔗糖和糖精，但摄入更少的奎宁；因此，对蔗糖和糖精的偏好与鼓索结果呈正相关，而对氯化钠和奎宁的厌恶与鼓索结果呈负相关。尽管如此，两种小鼠品系中参与味觉受体和/或鼓索（其转导具有不同感知品质的味觉刺激）的结构的基因是不同的。 (C) 1999 爱思唯尔科学公司。
Behavioral studies suggest that there are significant differences in the taste systems of the inbred mouse (Mus musculus) strains: C57BL/6J (B6) and DBA/2J (D2). In an attempt to understand the biological basis of the behavioral differences, we recorded whole-nerve chorda tympani responses to taste solutions and compared the results to intake of similar solutions in nondeprived mice. Stimuli included a test series composed of 0.1 M sodium chloride, 0.3 M sucrose, 10 mM sodium saccharin, 3 mM hydrochloric acid, and 3 mM quinine hydrochloride, as well as concentration series for the same substances. Neural activity of the chorda tympani that was evoked by sucrose, saccharin, or NaCl was greater in B6 than D2 mice; and neural threshold for sucrose was lower in B6 mice, but neural thresholds for HCl and quinine were lower in D2 mice. B6 mice drank more sucrose and saccharin but less quinine than D2 mice; thus, sucrose and saccharin preference were positively correlated, but NaCl and quinine aversiveness were negatively correlated with the chorda tympani results. Nonetheless, genes involved in the structuring of taste receptors and/or the chordae tympani, which transduce taste stimuli having diverse perceptual qualities, differ for the two mouse strains. (C) 1999 Elsevier Science Inc.