Folic acid treatment of Zambian children with moderate to severe malaria anemia
Folic acid treatment of Zambian children with moderate to severe malaria anemia
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DOI：
10.4269/ajtmh.2006.74.986
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Greenwood, Brian
中科院分区：
文献类型：
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作者：
Mulenga, Modest;Malunga, Phidelis;Greenwood, Brian
叶酸对疟疾贫血儿童是否有帮助仍有争议。因此，我们进行了一项随机、安慰剂对照试验，在赞比亚疟疾贫血儿童中进行了为期14天的叶酸（1 mg/d）治疗，这些儿童接受了磺胺嘧啶/乙胺嘧啶（SP）或阿托伐醌/氯胍（AP）治疗。在接受SP治疗的儿童中，在治疗开始后第3、7和14天，接受叶酸治疗的儿童的寄生虫血症患病率高于接受安慰剂治疗的儿童，第3天的差异具有统计学意义（P = 0.013）。叶酸治疗对AP治疗儿童的寄生虫血症没有影响。在治疗开始后第14天和第28天，叶酸给药导致红细胞压积比安慰剂组略有增加。
Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia treated with either sulfadoxine/pyrimethamine (SP) or atovaquone/proguanil (AP). Among children who received SP, the prevalence of parasitemia was higher in children treated with folic acid than among those given placebo at days 3, 7, and 14 after the start of treatment, and the difference at day 3 was statistically significant (P = 0.013). Folic acid treatment had no effect on parasitemia in children treated with AP. Administration of folic acid led to a small increase in packed cell volume over that seen in the placebo group at days 14 and 28 after the start of treatment.