Indirect oral immunization of captive vampires, Desmodus rotundus
Indirect oral immunization of captive vampires, Desmodus rotundus
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DOI：
10.1016/j.virusres.2005.03.013
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发表时间：
2005-07-01
期刊：
影响因子：
5
通讯作者：
Massad, E
中科院分区：
文献类型：
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作者：
Almeida, MF;Martorelli, LFA;Massad, E
用牛痘-狂犬病重组病毒(V-RG)疫苗对圈养的食血蝙蝠(Desmodus Rotundus)进行了试验。疫苗在中性载体(凡士林)中应用，传播在一到两只媒介蝙蝠的背部，然后重新引入它们的群体。我们的假设是，就像吸血蝙蝠用杀吸血鬼糊剂控制的情况一样，通过糊剂给一只蝙蝠注射V-RG疫苗可以间接保护同一组蝙蝠前面的其他蝙蝠。对八组受试者进行了测试。用来攻击蝙蝠的狂犬病病毒株是从一只自然感染的嗜血蝙蝠(Desmodus Rotundus)中分离出来的。病毒攻击后的存活率在42.8%~71.4%之间。结果令人鼓舞，因为大量没有接种疫苗的蝙蝠在挑战中幸存下来。该疫苗被证明对食血蝙蝠是安全的和免疫原性的。未见对痘苗病毒的不良反应。(C)2005年，爱思唯尔出版。
A vaccinia-rabies lycoprotein recombinant virus (V-RG) vaccine was tested in hematophagous bats (Desmodus rotundus) kept in captivity. The vaccine was applied in a neutral vehicle (Vaseline) spread on the back of one or two vector bats, which were then reintroduced into their groups. Our hypothesis was that, as in the case of vampire bat control by vampiricide paste, the administration of V-RG vaccine through paste to one bat could indirectly protect other bats front the same group. Eight groups were tested. The rabies virus strain used to challenge the bats was isolated from a naturally infected hematophagous bat (Desmodus rotundus). The survival proportion after the virus challenge ranged between 42.8 and 71.4%. The results are encouraging because a significant number of bats that did not receive the vaccine survived the challenge. The vaccine was shown to be safe and immunogenic to hematophagous bats. No adverse effects to vaccinia virus were observed. (c) 2005 Published by Elsevier B.V.