Influenza virus genetics
Influenza virus genetics
复制标题
DOI：
10.1016/s0753-3322(00)89026-5
复制
发表时间：
2000-05-01
影响因子：
7.5
通讯作者：
Brown, EG
中科院分区：
文献类型：
--
作者：
Brown, EG
在了解甲型流感病毒在细胞培养物中复制的过程方面取得了重大进展；然而，人们对疾病中病毒与宿主相互作用的遗传控制知之甚少。本综述概述了流感病毒生物学的遗传分析。介绍了甲型流感病毒各个基因的功能图谱以及我们目前对发病机制的了解状况。流感具有分段的基因组，因此可以获得包含源自不同病毒的基因组片段的新组合的重配体。这是一种非常有用的遗传工具，也是流感进化和生物学的一个重要方面。人类流感病毒源自禽类流感病毒株，因此流感感染本质上是一种人畜共患病。然而，流感病毒株是宿主限制的，禽类病毒株必须适应人类宿主。因此，宿主范围以及与宿主因素的相互作用问题是流感病毒在人类中引起疾病的能力的重要决定因素。宿主范围受到限制主要是由于核糖核衣壳和病毒受体之间的宿主特异性相互作用。抑制流感感染的药物有两类：盐酸金刚烷胺和神经氨酸酶抑制剂。介绍了这些药物的作用方式和耐药性基础。还讨论了抗病毒治疗的前瞻性目标。 (C) 2000 年科学与医学版 Elsevier SAS。
Significant progress has been made in understanding the process of influenza A virus replication in cell culture; however, much less is known about the genetic control of virus-host interactions in disease. This review provides an overview of the genetic analysis of influenza virus biology. The functional map of the individual genes of influenza A virus is presented as well as the status of our current understanding of pathogenesis. Influenza has a segmented genome so it is possible to obtain reassortants that contain novel combinations of genome segments derived from different viruses. This is a very useful genetic tool and is also an important aspect of influenza evolution and biology. Human influenza viruses originate from avian strains of influenza virus so that influenza infection is at its basis a zoonosis. Influenza virus strains are host-restricted, however, and avian strains must be adapted to the human host. So questions of host-range and interaction with host factors are important determinants of the ability of influenza virus to cause disease in humans. Host-range is restricted primarily due to host-specific interactions of the ribonucleocapsid and the viral receptor. There are two classes of drugs for inhibiting influenza infection, amantadine HCl and neuraminidase inhibitors. The mode of action and basis for resistance to these drugs are presented. Prospective targets for antiviral therapy are also discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.