Recurrent aciclovir‐resistant herpes simplex in a child with Wiskott–Aldrich syndrome
Recurrent aciclovir‐resistant herpes simplex in a child with Wiskott–Aldrich syndrome
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Wiskott-Aldrich 综合征儿童复发性阿昔洛韦耐药单纯疱疹
DOI：
10.1046/j.1365-2133.1998.02374.x
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发表时间：
1998
影响因子：
10.3
通讯作者：
K. Itoh
中科院分区：
文献类型：
--
作者：
Masayuki Saijo;T. Suzutani;K. Murono;Y. Hirano;K. Itoh
一例患有Wiskott-Aldrich综合征的男孩患有胸苷激酶（TK）改变和阿昔洛韦耐药的1型单纯疱疹病毒（HSV-1）皮肤感染。他于1993年3月8岁时左眼周围出现严重的单纯疱疹。分离出HSV-1菌株TAS，并显示其对阿昔洛韦敏感（50%抑制浓度（IC 50）0.23 μg/mL）。 他接受静脉内（i. v.）高剂量阿昔洛韦，2 mg/kg/h，产生改善。 大约1年后（1994年5月），他的面部、手臂、生殖器、背部和足部出现严重的单纯疱疹感染。开始静脉注射阿昔洛韦（2 mg/kg/h）治疗，但皮肤病变未改善。 分离出HSV-1菌株TAR，并显示对阿昔洛韦具有耐药性（IC 50 36 μg/mL）。 HSV-1 TAR和TAS对阿糖腺苷敏感（IC 50分别为4.4和2.9 μg/mL）。 用15-20 mg/kg/天的阿糖腺苷静脉内治疗皮肤病变，并令人满意地愈合。 然而，1995年3月，患者左眼周围再次出现严重的单纯疱疹感染。分离出HSV-1菌株R95，并显示对阿昔洛韦具有耐药性（IC 50 36 μg/mL）。 HSV-1 TAR和R95对阿昔洛韦的敏感性降低与病毒TK活性降低和阿昔洛韦磷酸化活性丧失相关。
A boy with Wiskott–Aldrich syndrome suffered from thymidine kinase (TK)‐altered and aciclovir‐resistant herpes simplex virus type 1 (HSV‐1) skin infections. He presented with severe herpes simplex around the left eye in March 1993 at the age of 8 years. HSV‐1 strain TAS was isolated and was shown to be susceptible to aciclovir (50% inhibitory concentration (IC50) 0.23 μg/mL). He was treated with intravenous (i.v.) high dose aciclovir, 2 mg/kg per h, which produced an improvement. About 1 year later (May 1994), a severe herpes simplex infection appeared on his face, arm, genitalia, back and foot. Treatment with i.v. aciclovir, 2 mg/kg per h, was initiated, but the skin lesions did not improve. HSV‐1 strain TAR was isolated and was shown to be resistant to aciclovir (IC50 36 μg/mL). HSV‐1 TAR and TAS were susceptible to vidarabine (IC50 4.4 and 2.9 μg/mL, respectively). The skin lesions were treated with i.v. vidarabine, 15–20 mg/kg per day, and healed satisfactorily. However, in March 1995, the patient again experienced a severe herpes simplex infection around the left eye. HSV‐1 strain R95 was isolated and was shown to be resistant to aciclovir (IC50 36 μg/mL). Diminished sensitivity of HSV‐1 TAR and R95 to aciclovir was associated with reduced viral TK activity and loss of aciclovir phosphorylation activity.
影响因子：
5.1
作者：
SULLIVAN, KE;MULLEN, CA;WINKELSTEIN, JA
通讯作者：
WINKELSTEIN, JA
DOI：
10.1093/infdis/161.6.1078
发表时间：
1990-06
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
S. Safrin;T. Assaykeen;S. Follansbee;J. Mills
通讯作者：
S. Safrin;T. Assaykeen;S. Follansbee;J. Mills