Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes
Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes
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DOI：
10.1902/jop.2007.060349
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发表时间：
2007-06-01
影响因子：
4.3
通讯作者：
Sculean, Anton
中科院分区：
文献类型：
--
作者：
Dori, Ferenc;Huszar, Tamas;Sculean, Anton
背景资料：与单独使用开放式皮瓣清创术（OFD）、单独使用无机牛骨矿物质（ABBM）或单独使用引导组织再生（GTR）的治疗相比，使用富血小板血浆（PRP）+无机牛骨矿物质（ABBM）+引导组织再生（GTR）组合的再生牙周治疗已被证明可显著提高探查深度减少和临床附着水平增加。然而，没有数据评估与ABBM + GTR治疗相比，PRP的使用在多大程度上可以额外增强治疗的临床结局。本研究旨在临床评估PRP对ABBM和GTR治疗的深部骨内缺损愈合的影响，通过不可吸收的膨体聚四氟乙烯（ePTFE）membrane.Methods：24例晚期慢性牙周病患者，显示一个骨内缺损，随机治疗与PRP + ABBM + GTR或ABBM + GTR的组合。在基线和治疗后1年评价以下临床参数：菌斑指数（PI）、牙龈指数（GI）、探诊出血（BOP）、探诊深度（PD）、牙龈退缩（GR）和临床附着水平（CAL）。主要结果变量是CAL。结果：两组之间在基线时观察到的任何研究参数均无差异。所有患者均顺利愈合。治疗后1年，PRP + ABBM + GTR治疗部位的平均PD从8.6 ± 1.7 mm降至3.1 ± 1.3 mm（P < 0.001），平均CAL从10.3 ± 1.4 mm降至5.7 ± 1.6 mm（P < 0.001）。在ABBM + GTR治疗组中，平均PD从8.8 +/- 1.7 mm降至3.1 +/- 1.0 mm（P < 0.001），平均CAL从10.4 +/- 2.6 mm变为5.9 +/- 1.8 mm（P < 0.001）。在两组中，所有部位的CAL增益均为3 mm。83%的患者（即，在12个缺损中的10个中），92%（即，在12个缺损中的11个中）用ABBM + GTR治疗。在1年的reevaluation.Conclusion：在其范围内，本研究表明，在牙周骨内缺损再生治疗后1年，获得了最佳的临床结果与ABBM + GTR与非吸收性屏障，有或没有添加PRP的任何研究参数之间没有统计学显着差异。
Background: Regenerative periodontal therapy with a combination of platelet-rich plasma (PRP) + an anorganic bovine bone mineral (ABBM) + guided tissue regeneration (GTR) has been shown to result in significantly higher probing depth reductions and clinical attachment level gains compared to treatment with open flap debridement (OFD) alone, ABBM alone, or GTR alone. However, there are no data evaluating to what extent the use of PRP may additionally enhance the clinical outcome of the therapy compared to treatment with ABBM + GTR. This study aimed to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with ABBM and GTR by means of a non-resorbable expanded polytetrafluoroethylene (ePTFE) membrane.Methods: Twenty-four patients with advanced chronic periodontal disease and displaying one intrabony defect were randomly treated with a combination of either PRP + ABBM + GTR or ABBM + GTR. The following clinical parameters were evaluated at baseline and at 1 year after treatment: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). The primary outcome variable was CAL.Results: No differences in any of the studied parameters were observed at baseline between the two groups. Healing was uneventful in all patients. At 1 year after therapy, the sites treated with PRP + ABBM + GTR showed a reduction in mean PD from 8.6 +/- 1.7 mm to 3.1 +/- 1.3 mm (P < 0.001) and a change in mean CAL from 10.3 +/- 1.4 mm to 5.7 +/- 1.6 mm (P < 0.001). In the group treated with ABBM + GTR, mean PD was reduced from 8.8 +/- 1.7 mm to 3.1 +/- 1.0 mm (P < 0.001), and the mean CAL changed from 10.4 +/- 2.6 mm to 5.9 +/- 1.8 mm (P < 0.001). In both groups, all sites gained 3 mm of CAL. CAL gains A mm were measured in 83% (i.e., in 10 of 12 defects) of the cases treated with PRP + ABBM + GTR and in 92% (i.e., in 11 of 12 defects) treated with ABBM + GTR. No statistically significant differences in any of the studied parameters were observed between the two groups at 1-year reevaluation.Conclusion: Within its limits, the present study has shown that, at 1 year after regenerative therapy in periodontal intrabony defects, optimal clinical results were obtained with ABBM + GTR with a non-resorbable barrier, with or without the addition of PRP.