Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system
Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system
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DOI：
10.1016/s0008-6363(02)00851-9
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发表时间：
2003-04-01
影响因子：
10.8
通讯作者：
Yasuma, F
中科院分区：
文献类型：
--
作者：
Hayano, J;Yasuma, F
提出一个假说，解释了为什么呼吸性窦性心律失常（RSA）的幅度似乎与心脏迷走神经张力相关的生理原因。假设RSA是心肺系统的内在静息功能。虽然RSA是由心脏迷走神经流出的呼吸调节介导的，并且其幅度被用作心脏迷走神经活动的指标，但RSA本身反映了心肺相互作用。RSA在脊椎动物的整个进化过程中普遍存在，表明它可能具有内在的生理作用。最近的研究表明，RSA通过在整个呼吸周期中匹配肺泡通气和毛细血管灌注来改善肺气体交换效率。这表明，在休息的动物和人类中，RSA可以通过在呼气期间抑制不必要的心跳和在灌注减弱阶段抑制无效通气来节省心脏和呼吸能量。此外，越来越多的证据表明RSA的幅度和迷走神经对心率的控制之间可能存在分离，这表明心脏迷走神经流出的呼吸调节与心脏迷走神经张力的调节是分开的和独立的。根据我们的假设，RSA和心脏迷走神经张力之间的明显关联被解释为间接后果;即，当心脏迷走神经张力随心肺系统静息水平的变化而变化时，RSA似乎与之平行变化。我们的假设似乎比假定RSA是心脏迷走神经活动的指标更符合RSA的生理和临床证据。(C)2003年欧洲心脏病学会。由Elsevier Science B. V.出版，版权所有。
A hypothesis is presented that explains the physiological reasons why the magnitude of respiratory sinus arrhythmia (RSA) appears to correlate with cardiac vagal tone. The hypothesis is that RSA is an intrinsic resting function of the cardiopulmonary system. Although RSA is mediated by respiratory modulation of cardiac vagal outflow and its magnitude is used as an index of cardiac vagal activity, RSA itself reflects cardiorespiratory interaction. RSA is universally observed among vertebrates throughout the evolution, suggesting that it may bear an intrinsic physiological role. Recent studies have shown that RSA improves pulmonary gas exchange efficiency by matching alveolar ventilation and capillary perfusion throughout respiration cycle.. This suggests that in resting animals and humans, RSA could save cardiac and respiratory energy by suppressing unnecessary heartbeats during expiration and ineffective ventilation during waning phases of perfusion. Furthermore, evidence is accumulating for possible dissociation between the magnitude of RSA and vagal control of heart rate, suggesting separated and independent regulations for respiratory modulation of cardiac vagal outflow from those for cardiac vagal tone. By our hypothesis, the apparent associations between RSA and cardiac vagal tone are explained as indirect consequences; i.e., whenever the cardiac vagal tone changes in response to the resting level of the cardiopulmonary system, RSA appears to change parallel to it. Our hypothesis seems more consistent with both physiological and clinical evidence about RSA than that presuming RSA is an index of cardiac vagal activity. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.