Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults
Relationship Between Mean Corpuscular Volume and Cognitive Performance in Older Adults
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DOI：
10.1111/jgs.12066
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发表时间：
2013-01-01
影响因子：
6.3
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
--
作者：
Gamaldo, Alyssa A.;Ferrucci, Luigi;Zonderman, Alan B.
目的探讨红细胞平均红细胞体积（MCV）与认知能力的关系。设计纵向。巴尔的摩老龄化纵向研究（BLSA）的设定样本。参与者：来自BLSA的827名参与者（平均年龄67岁，范围5096）。测量平均红细胞体积和其他一些血液指标，包括血红蛋白、铁、铁蛋白、维生素B12、叶酸、白细胞计数、白蛋白和红细胞沉降率。使用视觉记忆、言语记忆、语言、注意力、执行功能和整体精神状态的神经心理学测量来检查认知表现。结果即使在调整了潜在的混杂因素后，高MCV水平与较低的整体精神状态显著相关。即使在调整了潜在的混杂因素后，高MCV水平也与整体精神状态、长时间延迟记忆和注意力任务的高下降率显著相关。该研究结果证实了先前的观察，即老年人红细胞较大与认知功能较差有关。贫血和炎症似乎不能解释MCV和认知之间的关系。需要进一步的研究来阐明这种关联背后的机制。中华医学杂志，2013(1):84-89。
Objectives To examine the relationship between erythrocyte mean corpuscular volume (MCV) and cognitive performance over time. Design Longitudinal. Setting Sample from the Baltimore Longitudinal Study of Aging (BLSA). Participants Eight hundred twenty-seven participants from the BLSA (mean age 67, range 5096). Measurements Mean corpuscular volume and several other blood indices were measured, including hemoglobin, iron, ferritin, vitamin B12, folate, white blood cell count, albumin, and erythrocyte sedimentation rate. Cognitive performance was examined using neuropsychological measures of visual memory, verbal memory, language, attention, executive function, and global mental status. Results High MCV levels were significantly associated with lower global mental status even after adjusting for potential confounders. High MCV levels were also significantly associated with high rates of decline on tasks of global mental status, long delay memory, and attention, even after adjusting for potential confounders. Conclusion The findings confirm a previous observation that larger erythrocytes in older adults are associated with poorer cognitive function. Anemia and inflammation do not appear to explain the relationship between MCV and cognition. Further research is needed to clarify the mechanisms behind this association. J Am Geriatr Soc 61:84-89, 2013.