A randomized, blinded, controlled trial investigating the gastrointestinal health effects of drinking water quality
A randomized, blinded, controlled trial investigating the gastrointestinal health effects of drinking water quality
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DOI：
10.2307/3454818
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发表时间：
2001-08-01
影响因子：
10.4
通讯作者：
Fairley, CK
中科院分区：
文献类型：
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作者：
Hellard, ME;Sinclair, MI;Fairley, CK
在澳大利亚墨尔本进行了一项双盲、随机、对照试验，以确定饮用水对胃肠炎的影响。墨尔本是世界上少数几个从受保护的森林集水区抽取饮用水并进行最低限度水处理（仅氯化）的主要城市之一。600个家庭被随机分配到安装在厨房里的真实的或假的水处理装置（WTU）。真实的装置被设计用来清除病毒、细菌和原生动物。研究参与者在68周的观察期内完成每周健康日记，报告胃肠道症状。研究期间有2，669例高度可信的胃肠炎（HCG）病例（0.80例/人/年）。真实的WTU组与假WTU组相比的HCG发作率比值为0.99（95%置信区间，0.85-1.15，p = 0.85）。我们收集了795份来自胃肠炎患者的粪便标本，假WTU组中的病原体并不明显更常见。我们在墨尔本没有发现水媒疾病的证据。将这种方法应用于其他供水系统将使人们更好地了解人类健康与水质之间的关系。
A double-blinded, randomized, controlled trial was carried out in in Melbourne, Australia, to determine the contribution of drinking water to gastroenteritis, Melbourne is one of the few major cities in the world that draws drinking water from a protected forest catchment with minimal water treatment (chlorination only). Six hundred families were randomly allocated to receive either real or sham water treatment units (WTUs) installed in their kitchen. Real units were designed to remove viruses, bacteria, and protozoa. Study participants completed a weekly health diary reporting gastrointestinal symptoms during the 68-week observation period. There were 2,669 cases of highly credible gastroenteritis (HCG) during the study (0.80 cases/person/year). The ratio of HCG episode rates for the real WTU group compared to the sham WTU group was 0.99 (95% confidence interval, 0.85-1.15, p = 0.85). We collected 795 fecal specimens from participants with gastroenteritis, and pathogens were not more significantly common in the sham WTU group. We found no evidence of waterborne disease in Melbourne. The application of this methodology to other water supplies will provide a better understanding of the relationship between human health and water quality.