Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
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DOI：
10.1161/01.cir.0000149746.62908.bb
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发表时间：
2004-12-14
期刊：
影响因子：
37.8
通讯作者：
Kangawa, K
中科院分区：
文献类型：
--
作者：
Nagaya, N;Moriya, J;Kangawa, K
背景-生长激素释放肽是一种新的生长激素释放肽，也可诱导血管舒张，抑制交感神经活动，并通过生长激素非依赖性机制刺激进食。我们调查了生长素释放肽对左心室（LV）功能，运动能力，和肌肉萎缩的慢性心力衰竭（CHF）患者的影响。方法和结果-人合成生长素释放肽（2 μ g/kg，每天两次）静脉内给药10例CHF患者3周。在ghrelin治疗前后进行超声心动图、心肺运动试验、双能X线吸收测定法和血样采集。一个单一的管理ghrelin引起血清GH显着增加（25倍）。给予生长素释放肽三周导致血浆去甲肾上腺素显著降低（1132 +/- 188至655 +/- 134 pg/ mL; P < 0.001）。Ghrelin增加左室射血分数（27 +/- 2%至31 +/- 2%; P < 0.05），并伴有左室质量增加和左室收缩末期容积减少。用ghrelin治疗增加了运动时的峰值负荷和峰值耗氧量。Ghrelin改善肌肉萎缩，如肌肉力量和瘦体重增加所示。这些参数保持不变，在8例CHF谁没有收到ghrelin therapeutic.Conclusions -这些初步结果表明，反复给药的ghrelin改善左心室功能，运动能力，和肌肉萎缩的CHF患者。
Background - Ghrelin is a novel growth hormone - releasing peptide that also induces vasodilation, inhibits sympathetic nerve activity, and stimulates feeding through growth hormone - independent mechanisms. We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF).Methods and Results - Human synthetic ghrelin ( 2 mug/kg twice a day) was intravenously administered to 10 patients with CHF for 3 weeks. Echocardiography, cardiopulmonary exercise testing, dual x-ray absorptiometry, and blood sampling were performed before and after ghrelin therapy. A single administration of ghrelin elicited a marked increase in serum GH (25-fold). Three-week administration of ghrelin resulted in a significant decrease in plasma norepinephrine ( 1132 +/- 188 to 655 +/- 134 pg/ mL; P < 0.001). Ghrelin increased LV ejection fraction ( 27 +/- 2% to 31 +/- 2%; P < 0.05) in association with an increase in LV mass and a decrease in LV end-systolic volume. Treatment with ghrelin increased peak workload and peak oxygen consumption during exercise. Ghrelin improved muscle wasting, as indicated by increases in muscle strength and lean body mass. These parameters remained unchanged in 8 patients with CHF who did not receive ghrelin therapy.Conclusions - These preliminary results suggest that repeated administration of ghrelin improves LV function, exercise capacity, and muscle wasting in patients with CHF.