Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine
Evaluation of the Optic Nerve by Strain and Shear Wave Elastography in Patients With Migraine
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DOI：
10.1002/jum.14904
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发表时间：
2019-05-01
影响因子：
2.3
通讯作者：
Asal, Nese
中科院分区：
文献类型：
--
作者：
Sahan, Mehmet Hamdi;Dogan, Adil;Asal, Nese
目的应用剪切波和应变弹性成像技术研究偏头痛患者和正常人视神经的弹性特性。方法偏头痛组30例，其中有视觉先兆者16例，无视觉先兆者14例。这些是年龄和性别匹配的健康参与者，形成对照组。比较各组的剪切波和应变弹性成像结果。弹性成像检查采用6-15 MHz多频线阵换能器。结果30例偏头痛患者（男3例，女27例），平均年龄34.63 ± 10岁; 30例健康志愿者（男3例，女27例），平均年龄36.4 ± 10.5岁。在应变弹性模式中，观察到偏头痛患者的视神经硬化在统计学上不显着（P = 0.052）。对剪切波弹性模量值（9.8 +/- 3.34和12.3 +/- 5.25 kPa; P = 0.03）的分析显示，健康参与者和偏头痛患者之间的差异具有统计学意义。弹性模式和剪切模量的结果表明，有和没有视觉先兆的偏头痛之间的差异是不显著的（P > 0.05）。偏头痛患者病程与剪切模量呈正相关（r = 0.496; P <0.01）。结论偏头痛患者的视神经可能存在纤维化改变。弹性成像技术可以是有用的诊断工具，调查这些变化。
Objectives To investigate the optic nerve's elastic properties using shear wave and strain elastography in patients with migraine compared to healthy individuals. Methods The migraine group consisted of 30 patients (16 with visual auras and 14 without auras) who had previously had a diagnosis of migraine. These were age and sex matched with healthy participants to form the control group. The findings from shear wave and strain elastography in the groups were compared. The elastographic examination was performed with a 6-15-MHz multifrequency linear array transducer. Results The evaluation involved 30 patients with migraine (3 male and 27 female), whose mean age +/- SD was 34.63 +/- 10 years, and 30 healthy participants (3 males, 27 females), whose mean age was 36.4 +/- 10.5 years. In strain elasticity patterns, a statistically insignificant hardening of the optic nerve in the patients with migraine was observed (P = .052). Analysis of the shear wave elastic modulus values (9.8 +/- 3.34 and 12.3 +/- 5.25 kPa; P = .03) revealed that differences between the healthy participants and patients with migraine were statistically significant. The results for elasticity patterns and the shear modulus suggested that the differences between migraines with and without visual auras were insignificant (P > .05). A positive correlation was discovered between the duration of the disease and the shear modulus in the patients with migraine (r = 0.496; P < .01). Conclusions Histopathologic changes in the optic nerve may be seen in patients with migraine due to possible fibrotic changes. Elastographic techniques can be useful diagnostic tools for investigating these changes.